ArticleProgress in neuro-psychopharmacology & biological psychiatry2016
Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Deprescribing Antidepressants in Children and Adolescents: A Systematic Review of Discontinuation Approaches, Cross-Titration, and Withdrawal Symptoms.Journal of child and adolescent psychopharmacology · 2025Pooled it
- Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder.NeuroImage. Clinical · 2022Trial
- Error-related brain activity in pediatric anxiety disorders remains elevated following individual therapy: a randomized clinical trial.Journal of child psychology and psychiatry, and allied disciplines · 2018Trial
- Exploring Longitudinal Associations Among Error-Related Negativity, Perception of Interpersonal Events, and Internalizing Symptoms in Female Adolescents.Research on child and adolescent psychopathology · 2026Article
- Childhood behavioral inhibition and overcontrol: Risk for psychiatric and peer outcomes.Developmental psychology · 2026Article
- Error-Related Memory Biases Are Specific to Social Stimuli for Socially Anxious Individuals.bioRxiv : the preprint server for biology · 2025Article
- Maternal Social Phobia, but not Generalized Anxiety, Symptoms Interact with Early Childhood Error-Related Negativity to Prospectively Predict Child Anxiety Symptoms.Research on child and adolescent psychopathology · 2025Article
- Emotion Regulation Moderates the Prospective Association between ERN and Anxiety in Early Adolescence: An Age-Specific Moderation of Cognitive Reappraisal but not Expressive Suppression.Research on child and adolescent psychopathology · 2025Article
- Enhanced Performance Monitoring as a Transdiagnostic Risk Marker of the Anxiety and Obsessive-Compulsive Spectrum: The Role of Disorder Category, Clinical Status, Family Risk, and Anxiety Dimensions.Depression and anxiety · 2025Article
- Toward a mechanistic understanding of the role of error monitoring and memory in social anxiety.Cognitive, affective & behavioral neuroscience · 2024Article
- Multiple Adaptive Attention-Bias-Modification Programs to Alter Normative Increase in the Error-Related Negativity in Adolescents.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- The associations among sleep-related difficulties, anxiety, and error-related brain activity in youth.Biological psychology · 2024Article
- Towards a mechanistic understanding of the role of error monitoring and memory in social anxiety.bioRxiv : the preprint server for biology · 2023Article
- Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration.Current psychiatry reports · 2022Review
- Associations between lifetime stress exposure and the error-related negativity (ERN) differ based on stressor characteristics and exposure timing in young adults.Cognitive, affective & behavioral neuroscience · 2022Article
- The role of attentional shifting in the relation between error monitoring and anxiety in youth.Psychiatry research. Neuroimaging · 2022Article
- Reliability of reward ERPs in middle-late adolescents using a custom and a standardized preprocessing pipeline.Psychophysiology · 2022Article
- Spatial attention impairments are characterized by specific electro-encephalographic correlates and partially mediate the association between early life stress and anxiety.Cognitive, affective & behavioral neuroscience · 2022Article
- In the Face of Potential Harm: The Predictive Validity of Neural Correlates of Performance Monitoring for Perceived Risk, Stress, and Internalizing Psychopathology During the COVID-19 Pandemic.Biological psychiatry global open science · 2021Article
- Performance Monitoring and Mental Health During the COVID-19 Pandemic: Clarifying Pathways to Internalizing Psychopathology.Biological psychiatry global open science · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Increased error monitoring, as measured by the error-related negativity (ERN), has been shown to persist after treatment for obsessive-compulsive disorder in youth and adults; however, no previous studies have examined the ERN following treatment for related anxiety disorders. We used a flanker task to elicit the ERN in 28 youth and young adults (8-26years old) with primary diagnoses of generalized anxiety disorder (GAD) or social anxiety disorder (SAD) and 35 healthy controls. Patients were assessed before and after treatment with cognitive-behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRI), and healthy controls were assessed at a comparable interval. The ERN increased across assessments in the combined sample. Patients with SAD exhibited an enhanced ERN relative to healthy controls prior to and following treatment, even when analyses were limited to SAD patients who responded to treatment. Patients with GAD did not significantly differ from healthy controls at either assessment. Results provide preliminary evidence that enhanced error monitoring persists following treatment for SAD in youth and young adults, and support conceptualizations of increased error monitoring as a trait-like vulnerability that may contribute to risk for recurrence and impaired functioning later in life. Future work is needed to further evaluate the ERN in GAD across development, including whether an enhanced ERN develops in adulthood or is most apparent when worries focus on internal sources of threat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.