Evidence map›Paper›PMID 27495341›Full record

ArticleSurgical endoscopy2017

Superselective intra-arterial hepatic injection of indocyanine green (ICG) for fluorescence image-guided segmental positive staining: experimental proof of the concept.

Michele Diana, Yu-Yin Liu, Raoul Pop, Seong-Ho Kong, Andras Legnèr, Remy Beaujeux, Patrick Pessaux, Luc Soler, Didier Mutter, Bernard Dallemagne and 1 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04266548 (Superselective Intra-arterial Hepatic Injection of Indocyanine Green), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04266548 nacompletednot on this mapstarted 2018, after this paper: background citation

Superselective Intra-arterial Hepatic Injection of Indocyanine Green (ICG) for Fluorescence Image-guided Segmental Positive Staining

TypeinterventionalSponsorChang Gung Memorial HospitalRan2018 to 2020Enrolled8ConditionsHepatic CarcinomaArmsSuperselective Intra-arterial Hepatic Injection of Indocyanine Green (ICG) for Fluorescence Image-guided Segmental Positive Staining
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Accuracy of a new intraoperative cone beam CT imaging technique (Artis zeego II) compared to postoperative CT scan for assessment of pedicle screws placement and breaches detection.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michele DianaIRCAD, Research Institute Against Cancer of the Digestive System, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France. michele.diana@ircad.fr.ORCID 0000-0002-1390-8486
Yu-Yin LiuIRCAD, Research Institute Against Cancer of the Digestive System, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France.
Raoul PopInterventional Radiology Department, University Hospital of Strasbourg, Strasbourg Cedex, France.
Seong-Ho KongIHU-Strasbourg, Institute of Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France.
Andras LegnèrIHU-Strasbourg, Institute of Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France.
Remy BeaujeuxInterventional Radiology Department, University Hospital of Strasbourg, Strasbourg Cedex, France.
Patrick PessauxIHU-Strasbourg, Institute of Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France.
Luc SolerIRCAD, Research Institute Against Cancer of the Digestive System, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France.
Didier MutterDepartment of General and Digestive Surgery, University Hospital of Strasbourg, Strasbourg Cedex, France.
Bernard DallemagneIRCAD, Research Institute Against Cancer of the Digestive System, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France.
Jacques MarescauxIRCAD, Research Institute Against Cancer of the Digestive System, 1, place de l'Hôpital, 67091, Strasbourg Cedex, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative liver segmentation can be obtained by means of percutaneous intra-portal injection of a fluorophore and illumination with a near-infrared light source. However, the percutaneous approach is challenging in the minimally invasive setting. We aimed to evaluate the feasibility of fluorescence liver segmentation by superselective intra-hepatic arterial injection of indocyanine green (ICG). MATERIALS AND

methodsEight pigs (mean weight: 26.01 ± 5.21 kg) were involved. Procedures were performed in a hybrid experimental operative suite equipped with the Artis Zeego

resultsBright fluorescence signal enhancing the demarcation of target segments was obtained from 0.1 mg/mL, in matter of seconds. Correspondence between the volume of hepatic segments and arterial territories was confirmed by CT angiography. Higher background fluorescence noise was found after positive staining by intra-portal ICG injection, due to parenchymal accumulation and porto-systemic shunting.

conclusionsIntra-hepatic arterial ICG injection, rapidly highlights hepatic target segment borders, with a better signal-to-background ratio as compared to portal vein injection, in the experimental setting.

Indexed as

Coloring AgentsFluorescent DyesIndocyanine GreenAngiographyAnimalsFeasibility StudiesHepatic ArteryInfrared RaysInjections, Intra-ArterialIntraoperative CareLiverOptical ImagingPortal VeinStaining and LabelingSus scrofaSwineColoring AgentsFluorescent DyesIndocyanine GreenFluorescence-guided surgeryHepatic segmentationImage-guided surgeryIndocyanine green (ICG)Intra-arterial ICG injectionLaparoscopic liver surgeryPositive staining

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.