ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2016
Giant cell arteritis: ophthalmic manifestations of a systemic disease.
Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Paroxysmal Neurology: a Guide to Diagnosing Transient Neurologic Dysfunction in Adults and Adolescents.Current neurology and neuroscience reports · 2025Review
- Different clinical presentations of persistent placoid maculopathy: a case series.BMC ophthalmology · 2025Article
- [Ocular hypotonia as first manifestation of giant cell arteritis].Die Ophthalmologie · 2023Article
- Frequency of visual involvement in a 10-year interdisciplinary cohort of patients with giant cell arteritis.Clinical medicine (London, England) · 2023Article
- Color Doppler Eye Ultrasonography in giant cell arteritis: differential diagnosis between arteritic and non-arteritic sudden blindness.Journal of ultrasound · 2023Article
- Biopsy-Proven Giant Cell Arteritis Associated Vision Loss in Chinese Subjects: A Case Series and Review of the Literature.Neuro-ophthalmology (Aeolus Press) · 2023Article
- Rare Ischemic Complications of Giant Cell Arteritis: Case Series and Literature Review.The American journal of case reports · 2022Review
- Article
- Choroidal ischemia as one cardinal sign in giant cell arteritis.International journal of retina and vitreous · 2022Article
- Arteritic anterior ischemic optic neuropathy with hypotony, an alarming sign of severe form of giant cell arteritis.Indian journal of ophthalmology · 2022Article
- Giant Cell Arteritis: Updates and Controversies.Frontiers in ophthalmology · 2022Review
- Bridging the Gap between Ophthalmology and Emergency Medicine in Community-Based Emergency Departments (EDs): A Neuro-Ophthalmology Guide for ED Practitioners.Clinics and practice · 2021Article
- Role of temporal artery resection in Horton's arteritis (Review).Experimental and therapeutic medicine · 2021Review
- Characterization of visual manifestations and identification of risk factors for permanent vision loss in patients with giant cell arteritis.Clinical rheumatology · 2021Article
- Very Poor Visual Acuity in Non-Arteritic Anterior Ischaemic Optic Neuropathy.Neuro-ophthalmology (Aeolus Press) · 2021Article
- Training in and comfort with diagnosis and management of ophthalmic emergencies among emergency medicine physicians in the United States.Eye (London, England) · 2020Article
- Giant Cell Arteritis: The Experience of Two Collaborative Referral Centers and an Overview of Disease Pathogenesis and Therapeutic Advancements.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Vessels in full view: preserved vascular clarity in acute arteritic anterior ischaemic optic neuropathy.Acta ophthalmologica · 2019Review
- Predictive value of positive temporal artery biopsies in patients with clinically suspected giant cell arteritis considering temporal artery ultrasound findings.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Orbital Vasculitides-Differential Diagnosis.Current rheumatology reports · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGiant cell arteritis (GCA) is a systemic granulomatous vasculitis, primarily affecting medium-large arteries. It has a predilection for the aorta and its major branches, including the carotid and vertebral arteries. Ophthalmic artery involvement frequently leads to irreversible visual loss, and therefore GCA is one of the few true ophthalmic emergencies. GCA, although classified as a large vessel vasculitis, is known to affect smaller-sized vessels, resulting in a multiplicity of signs in the eye, some of which are often missed. PURPOSE: We set out to highlight some of the less frequently observed clinical signs, which may provide clues to clinically diagnosing GCA in patients presenting with non-classical features and inconclusive inflammatory markers.
methodsWe review the literature and describe the diverse ocular features and some of the systemic findings that can be associated with GCA.
resultsAlthough the most common ocular manifestation of GCA is anterior ischaemic optic neuropathy, the clinical presentation of GCA can vary dramatically. In the absence of obvious ocular involvement, more subtle ophthalmic signs of anterior segment ischaemia, such as hypotony and anisocoria, may be present at the time of initial clinical examination.
conclusionThere are no specific biomarkers for disease to date; therefore, pertinent history and clinical examination can guide towards diagnosis in the acute setting. The diagnostic process is not always straightforward, yet appropriate and prompt diagnosis is critical to enable timely intervention and prevent significant morbidity.
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