ArticleBMC family practice2016
Suicide risk in primary care patients diagnosed with a personality disorder: a nested case control study.
Article in BMC family practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Psychological therapies for people with borderline personality disorder.The Cochrane database of systematic reviews · 2020Pooled it
- Personality disorder diagnoses in UK Autistic people: Evidence from a matched cohort study.Autism : the international journal of research and practice · 2026Article
- Complex mental health difficulties: a mixed-methods study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Complex mental health difficulties in primary care: a scoping review with thematic synthesis.BJGP open · 2025Article
- Unravelling associations of personality traits, emotion regulation strategies, coping styles, and psychopathology with suicide risk in university students: a network perspective.BMC psychiatry · 2025Article
- Evaluation of the Personality Disorder Positive Outcomes Programme (PDPOP) in general practice: an evaluation.BJGP open · 2025Article
- Importance of investigating vulnerabilities in health and social service provision among requestors of medical assistance in dying.Lancet regional health. Americas · 2024Review
- Article
- The effectiveness of digital delivery versus group-based face-to-face delivery of the English National Health Service Type 2 Diabetes Prevention Programme: a non-inferiority retrospective cohort comparison study.BMC health services research · 2023Article
- Referral to the NHS Diabetes Prevention Programme and conversion from nondiabetic hyperglycaemia to type 2 diabetes mellitus in England: A matched cohort analysis.PLoS medicine · 2023Observational
- Application of Machine Learning Techniques to Help in the Feature Selection Related to Hospital Readmissions of Suicidal Behavior.International journal of mental health and addiction · 2022Article
- Cluster B versus Cluster C Personality Disorders: A Comparison of Comorbidity, Suicidality, Traumatization and Global Functioning.Behavioral sciences (Basel, Switzerland) · 2022Article
- Holistic community-based group parenting programs for mothers with maternal mental health issues help address a growing public health need for a diversity of vulnerable mothers, children and families: Findings from an action research study.Frontiers in global women's health · 2022Article
- Childbearing and mortality among women with personality disorders: nationwide registered-based cohort study.BJPsych open · 2020Article
- Sex, Gender, and Suicidal Behavior.Current topics in behavioral neurosciences · 2020Article
- Repeated Police Mental Health Act Detentions in England and Wales: Trauma and Recurrent Suicidality.International journal of environmental research and public health · 2019Article
- Borderline Personality Disorder and Violence Toward Self and Others: A National Study.Journal of personality disorders · 2019Article
- Coding algorithms for defining Charlson and Elixhauser co-morbidities in Read-coded databases.BMC medical research methodology · 2019Article
- Risk factors for self-harm in people with epilepsy.Journal of neurology · 2018Article
- Risk of Unnatural Mortality in People With Epilepsy.JAMA neurology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPersonality disorder (PD) is associated with elevated suicide risk, but the level of risk in primary care settings is unknown. We assessed whether PD among primary care patients is linked with a greater elevation in risk as compared with other psychiatric diagnoses, and whether the association is modified by gender, age, type of PD, and comorbid alcohol misuse.
methodsUsing data from the UK Clinical Practice Research Datalink, 2384 suicides were matched to 46,899 living controls by gender, age, and registered practice. Prevalence of PD, other mental disorders, and alcohol misuse was calculated for cases and controls separately and conditional logistic regression models were used to estimate exposure odds ratios. We also fitted gender interaction terms and formally tested their significance, and estimated gender age-specific effects.
resultsWe found a 20-fold increase in suicide risk for patients with PD versus no recorded psychiatric disorder, and a four-fold increase versus all other psychiatric illnesses combined. Borderline PD and PD with comorbid alcohol misuse were associated with a 37- and 45-fold increased risk, respectively, compared with those with no psychiatric disorders. Relative risks were higher for female than for male patients with PD. Significant risks associated with PD diagnosis were identified across all age ranges, although the greatest elevations were in the younger age ranges, 16-39 years.
conclusionsThe large elevation in suicide risk among patients diagnosed with PD and comorbid alcohol misuse is a particular concern. GPs have a potentially key role to play in intervening with patients diagnosed with PD, particularly in the presence of comorbid alcohol misuse, which may help reduce suicide risk. This would mean working with specialist care, agreed clinical pathways and availability of services for comorbidities such as alcohol misuse, as well as opportunities for GPs to develop specific clinical skills.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.