Evidence map›Paper›PMID 27495262›Full record

Trial reportClinical & experimental ophthalmology2017

Performance of real-world functional vision tasks by blind subjects improves after implantation with the Argus® II retinal prosthesis system.

Gislin Dagnelie, Punita Christopher, Aries Arditi, Lyndon da Cruz, Jacque L Duncan, Allen C Ho, Lisa C Olmos de Koo, José-Alain Sahel, Paulo E Stanga, Gabriele Thumann and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical & experimental ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Observational
  8. Motion perception with visual prostheses.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Static or Temporal? Semantic Scene Simplification to Aid Wayfinding in Immersive Simulations of Bionic Vision.Proceedings of the ACM Symposium on Virtual Reality Software and Technology. ACM Symposium on Virtual Reality Software and Technology · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Bioengineering strategies for restoring vision.Nature biomedical engineering · 2023
    Review
  19. Article
  20. Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gislin DagnelieLions Vision Research and Rehab Center, Johns Hopkins University, Baltimore, Maryland, USA.
Punita ChristopherSecond Sight Medical Products Inc, Sylmar, California, USA.
Aries ArditiLighthouse Guild, New York, New York, USA.
Lyndon da CruzMoorfields Eye Hospital, London, UK.
Jacque L DuncanUniversity of California, San Francisco, California, USA.
Allen C HoWills Eye Hospital, Philadelphia, Pennsylvania, USA.
Lisa C Olmos de KooDepartment of Ophthalmology, University of Southern California, Los Angeles, California, USA.
José-Alain SahelQuinze-Vingts National Ophthalmology Hospital, Paris, France.
Paulo E StangaManchester Royal Eye Hospital, Manchester, UK.
Gabriele ThumannGeneva University Hospital, Geneva, Switzerland.
Yizhong WangRetina Foundation of the Southwest, Dallas, Texas, USA.
Maura ArsieroSecond Sight Medical Products Inc, Sylmar, California, USA.
Jessy D DornSecond Sight Medical Products Inc, Sylmar, California, USA.
Robert J GreenbergSecond Sight Medical Products Inc, Sylmar, California, USA.
Argus® II Study Group

Funding

Research/Development of Artificial Rentinas for the BlindR01EY012893 · NEI · SECOND SIGHT MEDICAL PRODUCTS, INC. · PI GREENBERG, ROBERT JAY · 2006 to 2010
$12.9M
Development and Testing of Low Vision Assessment Tools for Retinal Prostheses.RC3EY020778 · NEI · SECOND SIGHT MEDICAL PRODUCTS, INC. · PI GREENBERG, ROBERT JAY · 2010 to 2010
$3.0M
NEI NIH HHS R01 EY012893NEI NIH HHS RC3 EY020778
6 · The paper itself

Abstract

backgroundThe main objective of this study was to test Argus II subjects on three real-world functional vision tasks.

designThe study was designed to be randomized and prospective. Testing was conducted in a hospital/research laboratory setting at the various participating centres.

participantsTwenty eight Argus II subjects, all profoundly blind, participated in this study.

methodsSubjects were tested on the three real-world functional vision tasks: Sock Sorting, Sidewalk Tracking and Walking Direction Discrimination task

main outcome measuresFor the Sock Sorting task, percentage correct was computed based on how accurately subjects sorted the piles on a cloth-covered table and on a bare table. In the Sidewalk Tracking task, an 'out of bounds' count was recorded, signifying how often the subject veered away from the test course. During the Walking Direction Discrimination task, subjects were tested on the number of times they correctly identified the direction of testers walking across their field of view.

resultsThe mean percentage correct OFF versus ON for the Sock Sorting task was found to be significantly different for both testing conditions (t-test, P < 0.01). On the Sidewalk Tracking task, subjects performed significantly better with the system ON than they did with the system OFF (t-test, P < 0.05). Eighteen (18) of 27 subjects (67%) performed above chance with the system ON, and 6 (22%) did so with system OFF on the Walking Direction Discrimination task.

conclusionsArgus II subjects performed better on all three tasks with their systems ON than they did with their systems OFF.

Indexed as

Visual AcuityVisual ProsthesisBlindnessElectrodes, ImplantedFemaleFollow-Up StudiesHumansMaleMiddle AgedPersons with Visual DisabilitiesProspective StudiesProsthesis DesignRetinaWalkingactivities of daily livingclinical trialoutcome measuresretinal prosthesisvisual performance

Identifiers

PMID27495262
PMCPMC5293683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.