ArticleWorld journal of surgical oncology2016
Pneumatosis intestinalis after gefitinib therapy for pulmonary adenocarcinoma: a case report.
Article in World journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 41 citations in OpenAlex.
- Erlotinib-Induced Pneumatosis Intestinalis: A Case Report and Review of Literature.Respirology case reports · 2026Article
- The Challenge of Pneumatosis Intestinalis: A Contemporary Systematic Review.Journal of personalized medicine · 2024Review
- Review
- Article
- Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis.BMC cancer · 2018Article
- A case of recurrent pneumatosis intestinalis.Journal of surgical case reports · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPneumatosis intestinalis (PI) is defined as the presence of gas in the bowel wall and is a relatively rare finding. PI has been associated with various pathological conditions and medications. Although several chemotherapeutic agents and molecular targeted therapy agents are reported to be associated with PI, there have been few reports describing the association between the anti-epidermal growth factor receptor agent gefitinib, a tyrosine kinase inhibitor (TKI), and PI. The present report describes a case of PI secondary to gefitinib therapy. CASE PRESENTATION: An 80-year-old woman who had been diagnosed with recurrent lung adenocarcinoma presented with remarkable appetite loss, abdominal distension, and constipation after starting gefitinib therapy. A computed tomography (CT) scan of the abdomen revealed PI extending from the small intestine to the rectum. The patient was managed conservatively, and gefitinib therapy was discontinued. Subsequently, the symptoms improved and a follow-up abdominal X-ray showed a reduction in intramural air. After gefitinib was restarted, PI occurred three more times.
conclusionsAlthough PI is extremely rare, physicians should be aware of the risk of PI in patients undergoing gefitinib therapy.
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