ArticleMagnetic resonance in medicine2017
In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 142 citations in OpenAlex.
- Benign and Malignant Breast Lesions: Differentiation Using Microstructural Metrics Derived from Time-Dependent Diffusion MRI.Radiology. Imaging cancer · 2025Trial
- Application of MR Cytometry in Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer: A Comparative Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Diffusion MRI of the Body: Beyond PGSE-EPI.Journal of magnetic resonance imaging : JMRI · 2026Review
- Physics-Assisted Deep Learning Denoising for Stabilized IMPULSED dMRI Microenvironment Parameter Fitting.ArXiv · 2026Article
- Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.NMR in biomedicine · 2026Article
- Feasibility of predicting breast cancer Ki-67 expression using histogram features derived from time-dependent diffusion magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Time-dependent Diffusion MRI-based Microstructural Mapping Value for Predicting Meningioma Grade, Subtype, and Proliferative Activity.Radiology. Imaging cancer · 2026Article
- The value of time-dependent diffusion MRI in nasopharyngeal carcinoma: correlation with prognostic factors.European radiology · 2026Article
- Article
- The application value of time-dependent DWI in the differential diagnosis of benign and malignant breast lesions and microstructural feature analysis.BMC medical imaging · 2026Article
- The predictive value of MR cytometry in histological differentiation of rectal cancer: an exploratory study.European radiology · 2026Observational
- Time-dependent diffusion MRI differentiates atypical from conventional uterine leiomyomas: A preliminary study.European journal of radiology open · 2026Article
- Microstructural mapping of time-dependent diffusion MRI for predicting lymphovascular invasion in rectal cancer: a proof-of-concept investigation.Insights into imaging · 2026Article
- Strong-Gradient Diffusion-Weighted Imaging of Prostate Cancer Using an Inside-Out Nonlinear Gradient Coil.Magnetic resonance in medicine · 2026Article
- Time-dependent diffusion MRI for non-invasive differentiation of benign and malignant breast lesions and evaluation of proliferation index biomarkers.Breast cancer (Tokyo, Japan) · 2026Article
- Time-dependent diffusion MRI for differentiating non‑small cell lung‑cancer brain metastases from breast‑cancer brain metastases and gliomas.Neuroradiology · 2026Article
- Time-dependent diffusion MRI-based microstructural mapping for giant intracranial mesenchymal tumor with FET-CREB fusion: a case description.Quantitative imaging in medicine and surgery · 2026Article
- Lymph Node Metastases Prediction in Cervical Cancer Using Time-Dependent Diffusion MRI and Macromolecular Proton Fraction Imaging.Radiology. Imaging cancer · 2026Article
- Repeatability of in vivo MR cytometry for measuring cell size and density in healthy human livers.Magnetic resonance imaging · 2026Article
- Non-Invasive Detection of Prostate Cancer with Novel Time-Dependent Diffusion MRI and AI-Enhanced Quantitative Radiological Interpretation: PROS-TD-AI.Journal of imaging · 2026Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeA temporal diffusion MRI spectroscopy based approach has been developed to quantify cancer cell size and density in vivo.
methodsA novel imaging microstructural parameters using limited spectrally edited diffusion (IMPULSED) method selects a specific limited diffusion spectral window for an accurate quantification of cell sizes ranging from 10 to 20 μm in common solid tumors. In practice, it is achieved by a combination of a single long diffusion time pulsed gradient spin echo (PGSE) and three low-frequency oscillating gradient spin echo (OGSE) acquisitions. To validate our approach, hematoxylin and eosin staining and immunostaining of cell membranes, in concert with whole slide imaging, were used to visualize nuclei and cell boundaries, and hence, enabled accurate estimates of cell size and cellularity.
resultsBased on a two compartment model (incorporating intra- and extracellular spaces), accurate estimates of cell sizes were obtained in vivo for three types of human colon cancers. The IMPULSED-derived apparent cellularities showed a stronger correlation (r = 0.81; P < 0.0001) with histology-derived cellularities than conventional ADCs (r = -0.69; P < 0.03).
conclusionThe IMPULSED approach samples a specific region of temporal diffusion spectra with enhanced sensitivity to length scales of 10-20 μm, and enables measurements of cell sizes and cellularities in solid tumors in vivo. Magn Reson Med 78:156-164, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.