SynthesisMedicine2016
Washed cell salvage in surgical patients: A review and meta-analysis of prospective randomized trials under PRISMA.
Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04792814 (Intraoperative Cell Salvage and Retrograde Autologous Priming in Patients Undergoing Isolated Coronary Bypass Grafting and Conventional Aortic Valve Replacement.), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intraoperative Cell Salvage and Retrograde Autologous Priming in Patients Undergoing Isolated Coronary Bypass Grafting and Conventional Aortic Valve Replacement.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Cell salvage for minimising perioperative allogeneic blood transfusion in adults undergoing elective surgery.The Cochrane database of systematic reviews · 2023Pooled it
- Should Cell Salvage Be Used in Liver Resection and Transplantation? A Systematic Review and Meta-analysis.Annals of surgery · 2023Pooled it
- Effectiveness of intraoperative blood recovery in surgical patients at risk of transfusion: A rapid review.Hematology, transfusion and cell therapy · 2026Review
- The Cost of Downstream Adverse Outcomes Associated with Allogeneic Blood Transfusion: A Retrospective Observational Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Cell Salvage Using the Autotransfusion Device CATSmartTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Article
- [Cell salvage in obstetrics-Background and practical implementation].Die Anaesthesiologie · 2024Review
- Autologous cell salvage in off-pump coronary artery bypass surgery reduces post-operative complications: a retrospective weighted-matching analysis.General thoracic and cardiovascular surgery · 2024Article
- Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.World journal of emergency surgery : WJES · 2024Review
- Efficacy of intraoperative blood salvage and autotransfusion in living-donor liver transplantation: a retrospective cohort study.Korean journal of anesthesiology · 2024Article
- Association between routine cell salvage use for lower segment caesarean section and post-operative iron infusion and anemia.Archives of gynecology and obstetrics · 2024Article
- Extract from the 2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery - Patient Blood Management.Blood transfusion = Trasfusione del sangue · 2024Review
- Efficacy of Intraoperative Cell Salvage on Perioperative Blood Transfusion in Pelvic and Acetabular Surgery: A Matched Cohort Analysis.The Iowa orthopaedic journal · 2024Article
- Turbulence in surgical suction heads as detected by MRI.The journal of extra-corporeal technology · 2023Article
- Intraoperative Cell Savage, Infection and Organ Failure in Infective Endocarditis Patients-A Retrospective Single Center Evaluation.Journal of clinical medicine · 2023Article
- Article
- Cell Salvage at the ICU.Journal of clinical medicine · 2022Review
- Operating on Jehovah's Witnesses: A Challenging Surgical Issue.Journal of religion and health · 2022Article
- Preoperative anaemia and red blood cell transfusion in patients with aneurysmal subarachnoid and intracerebral haemorrhage - a multicentre subanalysis of the German PBM Network Registry.Acta neurochirurgica · 2022Observational
- Efficacy of Intraoperative Blood Salvage in Cerebral Aneurysm Surgery.Journal of clinical medicine · 2021Article
- In Vitro and In Vivo Comparison of Hemoglobin and Electrolytes Following the Collection of Cell Saver Blood Washed with Either Normal Saline or Plasma-Lyte A.The journal of extra-corporeal technology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCell salvage is commonly used as part of a blood conservation strategy. However concerns among clinicians exist about the efficacy of transfusion of washed cell salvage.
methodsWe performed a meta-analysis of randomized controlled trials in which patients, scheduled for all types of surgery, were randomized to washed cell salvage or to a control group with no cell salvage. Data were independently extracted, risk ratio (RR), and weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Data were pooled using a random effects model. The primary endpoint was the number of patients exposed to allogeneic red blood cell (RBC) transfusion.
resultsOut of 1140 search results, a total of 47 trials were included. Overall, the use of washed cell salvage reduced the rate of exposure to allogeneic RBC transfusion by a relative 39% (RR = 0.61; 95% CI 0.57 to 0.65; P < 0.001), resulting in an average saving of 0.20 units of allogeneic RBC per patient (weighted mean differences [WMD] = -0.20; 95% CI -0.22 to -0.18; P < 0.001), reduced risk of infection by 28% (RR = 0.72; 95% CI 0.54 to 0.97; P = 0.03), reduced length of hospital stay by 2.31 days (WMD = -2.31; 95% CI -2.50 to -2.11; P < 0.001), but did not significantly affect risk of mortality (RR = 0.92; 95% CI 0.63 to 1.34; P = 0.66). No statistical difference could be observed in the number of patients exposed to re-operation, plasma, platelets, or rate of myocardial infarction and stroke.
conclusionsWashed cell salvage is efficacious in reducing the need for allogeneic RBC transfusion and risk of infection in surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.