Observational studyMedicine2016
The association between biliary tract inflammation and risk of digestive system cancers: A population-based cohort study.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Advanced or metastatic biliary tract cancer in Japan: a study using the Japan Medical Data Center payer claims database.Journal of comparative effectiveness research · 2023Article
- Association of hepatocellular carcinoma with thiazolidinediones use: A population-based case-control study.Medicine · 2020Observational
- Weight loss might be an early clinical manifestation of undiagnosed cancer: a nation-based cohort study.BioMedicine · 2018Article
- Weight loss might be an early clinical feature of undiagnosed human immunodeficiency virus infection in Taiwan.BioMedicine · 2018Article
- Association between allopurinol use and Parkinson's disease in older adults.European geriatric medicine · 2018Article
- Association between oral corticosteroid use and pyogenic liver abscesses in a case-control study.BioMedicine · 2018Article
- Head and neck cancer associated with increased rate of pulmonary tuberculosis in a population-based cohort study.Medicine · 2017Article
- Population-based cohort study examining the association between splenectomy and empyema in adults in Taiwan.BMJ open · 2017Article
- Population-based cohort study investigating the correlation of diabetes mellitus with pleural empyema in adults in Taiwan.Medicine · 2017Observational
- Risk of contracting pneumonia among patients with predialysis chronic kidney disease: a population-based cohort study in Taiwan.BioMedicine · 2017Article
- Does pyogenic liver abscess increase the risk of delayed-onset primary liver cancer?: Evidence from a nationwide cohort study.Medicine · 2017Observational
- Use of Oral Corticosteroids and Risk of Hip Fracture in the Elderly in a Case-Control Study.Frontiers in pharmacology · 2017Article
- Population-Based Case-Control Study Assessing the Association between Statins Use and Pulmonary Tuberculosis in Taiwan.Frontiers in pharmacology · 2017Article
- Nationwide Case-Control Study Examining the Association between Tamoxifen Use and Alzheimer's Disease in Aged Women with Breast Cancer in Taiwan.Frontiers in pharmacology · 2017Article
- Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan.Frontiers in pharmacology · 2017Article
- Zolpidem Administration and Risk of Hepatocellular Carcinoma: A Case-Control Study in Taiwan.Frontiers in pharmacology · 2017Article
- Dipeptidyl Peptidase-4 Inhibitors Use and Relative Risk of Ischemic Cerebrovascular Disease in Type 2 Diabetic Patients in a Case-Control Study.Frontiers in pharmacology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between biliary tract inflammation (BTI) and digestive system cancers is unclear. This study aimed to evaluate the association between BTI and the risks of digestive system cancers.Using the Taiwan National Health Insurance claims data, information on a cohort of patients diagnosed with BTI (n = 4398) between 2000 and 2009 was collected. A comparison cohort of sex-, age-, and index year-matched persons without BTI (n = 17,592) was selected from the same database. The disease was defined by the ICD-9-CM. Both cohorts were followed until the end of 2010 and incidences of digestive system cancers were calculated.The results revealed an increase in adjusted hazard ratio (aHR) of biliary tract cancer (24.45; 95% confidence interval [CI]: 9.20-65.02), primary liver cancer (1.53; 95% CI: 1.07-2.18), and pancreatic cancer (3.10; 95% CI: 1.20-8.03) in patients with both gallbladder and BTI. The aHR of stomach cancer was also found to be increased (2.73; 95% CI: 1.28-5.81) in patients with gallbladder inflammation only. There were no differences in esophageal cancer (aHR: 0.82; 95% CI: 0.23-2.87) and colorectal cancer (aHR: 0.92; 95% CI: 0.59-1.45). The aHR for digestive system cancers increased by 3.66 times (95% CI: 2.50-5.35) and 12.20 times (95% CI: 8.66-17.17) in BTI visits frequency averaged 2 to 4 visits per year and frequency averaged ≥5 visits per year, respectively.Patients with BTI have significantly higher risk of digestive system cancers, particularly biliary tract, pancreatic, and primary liver cancers, compared with those who are without it.
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