Observational studyMedicine2016
The outcomes of patients with severe dengue admitted to intensive care units.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05938647 (Characteristics of Patients With Severe Dengue Admitted in Critical Care Units at Villavicencio, Colombia. A Retrospective Observational Trial.), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characteristics of Patients With Severe Dengue Admitted in Critical Care Units at Villavicencio, Colombia. A Retrospective Observational Trial.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Routine blood parameters of dengue infected children and adults. A meta-analysis.Pathogens and global health · 2023Pooled it
- Does dengue and COVID-19 co-infection have worse outcomes? A systematic review of current evidence.Reviews in medical virology · 2022Pooled it
- Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Global burden of dengue on healthcare systems: a meta-analysis of healthcare resource utilisation.EClinicalMedicine · 2026Article
- Assessing the burden of diabetes mellitus in dengue patients: A systematic review and meta-analysis.New microbes and new infections · 2026Article
- Article
- Severe dengue in adults admitted to intensive care units on réunion island: clinical spectrum, outcomes, and predictors of mortality.Critical care (London, England) · 2025Article
- In-Hospital Mortality in Mechanically Ventilated Children With Severe Dengue Fever: Explanatory Factors in a Single-Center Retrospective Cohort From Vietnam, 2013-2022.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- Excessive fluid resuscitation is associated with intensive care unit mortality in Pakistani patients with dengue shock syndrome.Acute and critical care · 2025Article
- Prognostic factors in severe dengue patients: A multi-center retrospective cohort study.PLoS neglected tropical diseases · 2025Article
- High frequency of severe liver dysfunction in critically ill Dengue patients in the French West Indies.Journal of intensive medicine · 2024Article
- Proceedings of the 6th Asia Dengue Summit, June 2023.PLoS neglected tropical diseases · 2024Article
- Article
- Comparative analysis of liver involvement caused by two DENV-2 lineages using an immunocompetent murine model.Scientific reports · 2021Article
- Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression.Journal of immunology research · 2021Observational
- Increased TNF-Journal of immunology research · 2021Observational
- Comparing machine learning with case-control models to identify confirmed dengue cases.PLoS neglected tropical diseases · 2020Article
- Atypical Presentation of Methicillin-SusceptiblePathogens (Basel, Switzerland) · 2020Article
- A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India.Indian journal of anaesthesia · 2020Article
- Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly.PLoS neglected tropical diseases · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Outcomes of adult patients with dengue infections requiring intensive care unit (ICU) admissions remain unclear. We assessed the clinical manifestations and prognostic factors of patients critically ill with severe dengue.This retrospective study was done in a tertiary referral hospital with 96 adult ICU beds. All of the patients with laboratory-confirmed severe dengue infections and admitted to the ICU were enrolled between July 31 and November 31, 2015, during the large outbreak period. The medical records of all the recruited patients were reviewed for the following information: age, gender, clinical manifestations, disease severity scores, underlying conditions, laboratory examinations, and outcomes. The primary endpoint was to find the predictors of ICU mortality.During the study period, 4787 patients with dengue infections required ICU admission. One hundred forty-three (2.99%) were critically ill (mean age: 69.7 years). Hypertension (n = 90, 62.9%) and diabetes mellitus (n = 70, 49.0%) were the 2 most common underlying diseases. Eighty critically ill patients (55.9%) had cobacterial infections, and 33 had cobacteremia. The hematologic system failed most often, followed by thoracic and cardiovascular systems. Fever was the most common presentation (n = 112; 78.3%), followed by anorexia (n = 47; 32.9%) and abdominal pain (n = 46; 32.2%). Overall, 33 patients died (mortality rate: 23.1%). Multivariate analysis showed that ICU mortality was significantly associated with lower Glasgow Coma Scale (GCS) scores, lower platelet counts before ICU discharge, and more organ failures.The number of severe dengue patients who require ICU admission remains high. The mortality rate was associated with lower GCS scores, lower platelet counts, and more organ failures. In addition, more than half of the critically ill dengue patients had comorbid bacterial infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.