Observational studyMedicine2016
Polymorphism in the IL4R gene and clinical features are associated with glioma prognosis: Analyses of case-cohort studies.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Impact ofPharmacogenomics and personalized medicine · 2023Article
- ARRDC3 polymorphisms may affect the risk of glioma in Chinese Han.Functional & integrative genomics · 2022Article
- The Impact ofPharmacogenomics and personalized medicine · 2022Article
- Insights from IgE Immune Surveillance in Allergy and Cancer for Anti-Tumour IgE Treatments.Cancers · 2021Review
- GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis.Molecular therapy. Nucleic acids · 2019Article
- LPP and RYR2 Gene Polymorphisms Correlate with the Risk and the Prognosis of Astrocytoma.Journal of molecular neuroscience : MN · 2019Article
- Impact of AKAP6 polymorphisms on Glioma susceptibility and prognosis.BMC neurology · 2019Article
- Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur Population: A Case-Control study.Molecular genetics & genomic medicine · 2019Article
- Impact of ANXA5 polymorphisms on glioma risk and patient prognosis.Journal of neuro-oncology · 2019Article
- The impact of genetic variants in IL1R2 on cervical cancer risk among Uygur females from China: A case-control study.Molecular genetics & genomic medicine · 2019Article
- Overexpression of NIMA-related kinase 2 is associated with poor prognoses in malignant glioma.Journal of neuro-oncology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory gene polymorphisms may be associated with glioma risk. The purpose of this study was to analyze effects of certain inflammatory gene and some clinical factors on patient survival.The clinical information of 269 glioma patients conceived operation from September 2010 to May 2014 to decide the 1-, 3-year survival rates according to follow-up results and analyze age, gender, the WHO classification, extent of surgical resection, radiotherapy and chemotherapy factors effects on prognosis. Survival distributions were estimated by using the Kaplan-Meier method and difference in the survival was tested using the log-rank test. To estimate the association between the IL4, IL13, IL10, IL4R SNPs, and PFS and OS in glioma, the HR and 95% CI were calculated by univariate Cox proportional hazards model. Multivariate Cox model were performed to compute adjusted HR and 95% CI. All data was analyzed with SPSS17.0 package. Extent of surgical resection, chemotherapy, and age are an important factor in glioma overall survival and progression-free survival overall. Extent of surgery and chemotherapy are important factors in astrocytoma overall survival. Univariate analysis showed that IL4R rs1801275 was significantly associated with overall survival of glioma and astrocytoma patients (P < 0.05). Multivariate Cox regression analysis showed that IL4R rs1801275 GG genotype could increase the death risk of glioma and astrocytoma patients (Glioma: hazard ratio [HR]: 4.897, 95% confidence limits [95% CI]: 1.962-12.222, P = 0.001; Astrocytoma: HR: 15.944, 95% CI: 4.019-63.253, P < 0.05).Our research results showed that extent of surgical resection, age, and chemotherapy affect the prognosis of glioma. The IL4R gene may affect the survival of glioma patients.
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