ArticlePloS one2016
Magnetic Particle Imaging for High Temporal Resolution Assessment of Aneurysm Hemodynamics.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Millisecond magnetic particle imaging of a cerebral aneurysm phantom with and without flow diverter stent.Communications engineering · 2026Article
- Imaging of Artificial Tumor Models in an Anatomical Breast Phantom with a Single-Sided Magnetic Particle Imaging Scanner.Tomography (Ann Arbor, Mich.) · 2026Article
- Advances in Vascular Diagnostics using Magnetic Particle Imaging (MPI) for Blood Circulation Assessment.Advanced healthcare materials · 2024Review
- iMPI: portable human-sized magnetic particle imaging scanner for real-time endovascular interventions.Scientific reports · 2023Article
- Development of Phantoms for Multimodal Magnetic Resonance Imaging and Magnetic Particle Imaging.Polymers · 2022Article
- [Magnetic particle imaging : From research to the prospect of clinical use].Radiologie (Heidelberg, Germany) · 2022Review
- Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles.Polymers · 2021Review
- Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging.Scientific reports · 2021Article
- Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery.Scientific reports · 2021Article
- Article
- In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles.Scientific reports · 2020Article
- Visualization of spatial and temporal temperature distributions with magnetic particle imaging for liver tumor ablation therapy.Scientific reports · 2020Article
- Magnetic iron oxide nanoparticles for imaging, targeting and treatment of primary and metastatic tumors of the brain.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Custom tissue engineered aneurysm models with varying neck size and height for early stage in vitro testing of flow diverters.Journal of materials science. Materials in medicine · 2020Article
- Cellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging.Scientific reports · 2020Article
- Human-sized magnetic particle imaging for brain applications.Nature communications · 2019Article
- A perspective on a rapid and radiation-free tracer imaging modality, magnetic particle imaging, with promise for clinical translation.The British journal of radiology · 2018Review
- Magnetic particle imaging in vascular medicine.Innovative surgical sciences · 2018Review
- Magnetic Particle Imaging (MPI): Experimental Quantification of Vascular Stenosis Using Stationary Stenosis Phantoms.PloS one · 2017Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this work was to demonstrate the capability of magnetic particle imaging (MPI) to assess the hemodynamics in a realistic 3D aneurysm model obtained by additive manufacturing. MPI was compared with magnetic resonance imaging (MRI) and dynamic digital subtraction angiography (DSA). MATERIALS AND
methodsThe aneurysm model was of saccular morphology (7 mm dome height, 5 mm cross-section, 3-4 mm neck, 3.5 mm parent artery diameter) and connected to a peristaltic pump delivering a physiological flow (250 mL/min) and pulsation rate (70/min). High-resolution (4 h long) 4D phase contrast flow quantification (4D pc-fq) MRI was used to directly assess the hemodynamics of the model. Dynamic MPI, MRI, and DSA were performed with contrast agent injections (3 mL volume in 3 s) through a proximally placed catheter. RESULTS AND DISCUSSION: 4D pc-fq measurements showed distinct pulsatile flow velocities (20-80 cm/s) as well as lower flow velocities and a vortex inside the aneurysm. All three dynamic methods (MPI, MRI, and DSA) also showed a clear pulsation pattern as well as delayed contrast agent dynamics within the aneurysm, which is most likely caused by the vortex within the aneurysm. Due to the high temporal resolution of MPI and DSA, it was possible to track the contrast agent bolus through the model and to estimate the average flow velocity (about 60 cm/s), which is in accordance with the 4D pc-fq measurements.
conclusionsThe ionizing radiation free, 4D high resolution MPI method is a very promising tool for imaging and characterization of hemodynamics in human. It carries the possibility of overcoming certain disadvantages of other modalities like considerably lower temporal resolution of dynamic MRI and limited 2D characteristics of DSA. Furthermore, additive manufacturing is the key for translating powerful pre-clinical techniques into the clinic.
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