ReviewPhysics in medicine and biology2016
Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy.
Review in Physics in medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- The effects and mechanisms of transcranial ultrasound stimulation combined with cognitive rehabilitation on post-stroke cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Trial
- Therapeutic potential of ultrasound for spinal cord injury.Neural regeneration research · 2026Article
- Three-dimensional passive acoustic mapping of high intensity focused ultrasound fields using sparse synthetic apertures from rotated one-dimensional linear arrays.Scientific reports · 2026Article
- Low-Intensity Pulsed Ultrasound in Peripheral and Central Nerve Repair: Mechanisms and Emerging Therapeutic Strategies.Journal of functional biomaterials · 2026Review
- Neuromodulation and rehabilitation of post-stroke cognitive impairment: challenges and prospects.Frontiers in psychiatry · 2026Review
- Aberration correction expands the treatment envelope for histotripsy in the liver.Physics in medicine and biology · 2025Article
- Sub-pitch plane-wave imaging for improved 3-D ultrasound imaging with a large pitch 2-D array.Biomedical engineering letters · 2025Article
- Ultrasonic rewarming of cryopreserved alginate encapsulated liver spheroids.Scientific reports · 2025Article
- Ultrasound system for precise neuromodulation of human deep brain circuits.Nature communications · 2025Article
- All-optically controlled phased-array for ultrasonics.Nature communications · 2025Article
- The synergistic potential of ultrasound and nanomaterials for enhanced diagnosis and therapy of head and neck cancers.Nanomedicine (London, England) · 2025Review
- A clinical case report on transcranial low-intensity focused ultrasound neuromodulation for central post-stroke pain.Frontiers in neuroscience · 2025Article
- Identifying new therapeutics for focused ultrasound-enhanced drug delivery in the management of glioblastoma.Frontiers in oncology · 2025Review
- Evaluating the accuracy of acoustic holograms for precise spatial targeting within the brain.NPJ acoustics · 2025Article
- Focused ultrasound heating in brain tissue/skull phantoms with 1 MHz single-element transducer.Journal of ultrasound · 2024Article
- Neurosurgical and pharmacological management of dystonia.World journal of psychiatry · 2024Review
- Treatment Planning and Aberration Correction Algorithm for HIFU Ablation of Renal Tumors.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Probability of Cavitation in a Custom Iron-Based Coupling Medium for Transcranial Magnetic Resonance-Guided Focused Ultrasound Procedures.Ultrasound in medicine & biology · 2023Article
- Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound.Scientific reports · 2023Article
- Focused ultrasound thalamotomy for tremor treatment impacts the cerebello-thalamo-cortical network.NPJ Parkinson's disease · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the body, which can be harnessed for a broad spectrum of therapeutic purposes, including tissue ablation, the targeting of therapeutic agents, and stem cell delivery. Phased array transducers enable electronic control over the beam geometry and direction, and can be tailored to provide optimal energy deposition patterns for a given therapeutic application. Their use in combination with modern medical imaging for therapy guidance allows precise targeting, online monitoring, and post-treatment evaluation of the ultrasound-mediated bioeffects. In the past there have been some technical obstacles hindering the construction of large aperture, high-power, densely-populated phased arrays and, as a result, they have not been fully exploited for therapy delivery to date. However, recent research has made the construction of such arrays feasible, and it is expected that their continued development will both greatly improve the safety and efficacy of existing ultrasound therapies as well as enable treatments that are not currently possible with existing technology. This review will summarize the basic principles, current statures, and future potential of image-guided ultrasound phased arrays for therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.