Evidence map›Paper›PMID 27494537›Full record

ArticleEnvironmental research2016

A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California.

Catherine Metayer, Ghislaine Scelo, Alice Y Kang, Robert B Gunier, Kyndaron Reinier, Suzanne Lea, Jeffrey S Chang, Steve Selvin, Janice Kirsch, Vonda Crouse and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
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  9. Incidence and Mortality Rates for Childhood Acute Lymphoblastic Leukemia in Puerto Rican Hispanics, 2012-2016.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Catherine MetayerUniversity of California, Berkeley, School of Public Health, Division of Epidemiology, Berkeley, CA, USA. Electronic address: cmetayer@berkeley.edu.
Ghislaine SceloInternational Agency for Research on Cancer, Lyon, France.
Alice Y KangUniversity of California, Berkeley, School of Public Health, Division of Epidemiology, Berkeley, CA, USA.
Robert B GunierUniversity of California, Berkeley, School of Public Health, Division of Environmental Health Sciences, Berkeley, CA, USA.
Kyndaron ReinierCedars-Sinai Medical Center, Heart Institute, Los Angeles, CA, USA.
Suzanne LeaEast Carolina University, Brody School of Medicine, Department of Public Health, Greenville, NC, USA.
Jeffrey S ChangNational Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
Steve SelvinUniversity of California, Berkeley, School of Public Health, Division of Epidemiology, Berkeley, CA, USA.
Janice KirschMedical oncologist and hematologist, Berkeley, CA, USA.
Vonda CrouseValley Children's Hospital, Madera, CA, USA.
Monique DoesDivision of Research, the Permanente Medical Group, Oakland, CA, USA.
Patricia QuinlanUniversity of California, San Francisco, Department of Medicine, San Francisco, CA, USA.
S Katharine HammondUniversity of California, Berkeley, School of Public Health, Division of Environmental Health Sciences, Berkeley, CA, USA.
University of California, Berkeley · USCedars-Sinai Medical Center · USCentre International de Recherche sur le Cancer · FRChildren's Hospital Central California · USColorado Permanente Medical Group · USEast Carolina University · USNational Health Research Institutes · TWUniversity of California, San Francisco · US

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MCHALE, CLIONA · 1987 to 2025
$74.6M
Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
Parental Occupational Pesticide Exposure Assessment and Childhood Leukemia RiskR03CA153048 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2011 to 2012
$103k
NCI NIH HHS R03 CA153048NIEHS NIH HHS P42 ES004705NIEHS NIH HHS R01 ES009137World Health Organization 001
6 · The paper itself

Abstract

purposeData on parental occupational exposures and risk of childhood leukemia lack specificity. Using 19 task-based job modules, we examined the relationship between occupational exposure to organic solvents and other compounds and the risk of leukemia in children.

methodsLatino (48%) and non-Latino (52%) children with acute lymphoblastic leukemia (ALL; n=670), acute myeloid leukemia (AML; n=104), and controls (n=1021) were enrolled in a study in California (2000-2008). Logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for socio-demographic factors.

resultsAmong children with non-Latino fathers, none of the exposures evaluated were associated with risks of ALL and AML. In contrast, exposure to any organic solvents in Latino fathers was associated with an increased risk of childhood ALL (OR=1.48; 95% CI: 1.01-2.16); in multivariable analyses, the OR for chlorinated hydrocarbons was 2.28 (95% CI: 0.97-5.37) while the ORs were close to one for aromatic hydrocarbons, glycol ethers, and other hydrocarbon mixtures. We also observed an increased risk of ALL with exposure to combustion exhaust/polycyclic aromatic hydrocarbons (PAHs) (ORs=1.70; 95% CI: 1.16-2.57, and 1.46; 95% CI: 0.94-2.26 with and without adjustment for chlorinated hydrocarbons, respectively). Moderately elevated risks of ALL were seen with exposure to metals, paints, and wood dust, although not statistically significant. An increased risk was reported for asbestos based on small numbers of exposed Latino fathers. No associations were reported between maternal exposures to any exposures and childhood ALL and AML.

conclusionsOur data support associations between paternal occupational exposures to chlorinated hydrocarbons, combustion exhaust, metals, and possibly asbestos and the risk of ALL in the children of Latino fathers only.

Indexed as

Air Pollutants, OccupationalOccupational ExposurePaternal ExposureAdultAsbestosCaliforniaCase-Control StudiesChildChild, PreschoolFemaleHispanic or LatinoHumansHydrocarbonsInfantInfant, NewbornLeukemia, Myeloid, AcuteAir Pollutants, OccupationalAsbestosHydrocarbonsMetalsSolventsVehicle EmissionsChemicalsChildhood leukemiaOccupational exposure

Identifiers

PMID27494537
PMCPMC5071154
OpenAlexW2506563537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.