ArticlePloS one2016
Epidemiology, Seasonality and Factors Associated with Rotavirus Infection among Children with Moderate-to-Severe Diarrhea in Rural Western Kenya, 2008-2012: The Global Enteric Multicenter Study (GEMS).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Understanding the Impact of Rainfall on Diarrhea: Testing the Concentration-Dilution Hypothesis Using a Systematic Review and Meta-Analysis.Environmental health perspectives · 2020Pooled it
- Temporal patterns and risk factors of diarrheal comorbidity among children aged < 5 years in rural western Kenya: Evidence from three consecutive enteric studies, 2008-2024.PLOS global public health · 2026Article
- Surveillance and Genotypic Distribution of Rotavirus Diarrhea in Children with Acute Gastroenteritis in Dhanbad, Jharkhand, India.Indian journal of pediatrics · 2025Observational
- Prolonged Hospitalization Among Children Aged < 5 Years Admitted With Acute Gastroenteritis at Siaya County Referral Hospital, in Rural Western Kenya: 2010-2020.Health science reports · 2025Article
- Epidemiological trends of diarrheal viruses in central and western Kenya before and after Rotavirus vaccine introduction.Tropical medicine and health · 2025Article
- Clinical Severity of Enteric Viruses Detected Using a Quantitative Molecular Assay Compared With Conventional Assays in the Global Enteric Multicenter Study.The Journal of infectious diseases · 2024Article
- Impact of Rotaviral Diarrhea on Child Growth in Sub-Saharan Africa and South Asia in the Global Enteric Multicenter Study.The American journal of tropical medicine and hygiene · 2024Article
- PivotalVaccines · 2022Article
- Article
- Seasonal synchronization of foodborne outbreaks in the United States, 1996-2017.Scientific reports · 2020Article
- Epidemiological Trends of Five Common Diarrhea-Associated Enteric Viruses Pre- and Post-Rotavirus Vaccine Introduction in Coastal Kenya.Pathogens (Basel, Switzerland) · 2020Article
- The seasonality of diarrheal pathogens: A retrospective study of seven sites over three years.PLoS neglected tropical diseases · 2019Article
- Seasonality of Rotavirus Hospitalizations at Costa Rica's National Children's Hospital in 2010-2015.International journal of environmental research and public health · 2019Article
- Rates of hospitalization and death for all-cause and rotavirus acute gastroenteritis before rotavirus vaccine introduction in Kenya, 2010-2013.BMC infectious diseases · 2019Article
- Evaluation of the performance of a multiplex reverse transcription polymerase chain reaction kit as a potential diagnostic and surveillance kit for rotavirus in Kenya.Tropical diseases, travel medicine and vaccines · 2019Article
- Analysis of Hierarchical Routine Data With Covariate Missingness: Effects of Audit & Feedback on Clinicians' Prescribed Pediatric Pneumonia Care in Kenyan Hospitals.Frontiers in public health · 2019Article
- Kin support and child health: Investigating two approaches in an African slum.Social science research · 2018Article
- Prevalence of rotavirus infection among children with acute diarrhoea after rotavirus vaccine introduction in Kenya, a hospital cross-sectional study.BMC pediatrics · 2018Article
- Molecular-Genetic Characterization of Human Rotavirus A Strains Circulating in Moscow, Russia (2009-2014).Virologica Sinica · 2018Article
- Spatial, temporal, and spatiotemporal analysis of under-five diarrhea in Southern Ethiopia.Tropical medicine and health · 2018Article
Corrections and comments
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Authors and funding
24 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate factors associated with rotavirus diarrhea and to describe severity of illness among children <5 years old with non-dysenteric, moderate-to-severe diarrhea (MSD) in rural western Kenya.
methodsWe analyzed data from children <5 years old with non-dysenteric MSD enrolled as cases in the Global Enteric Multicenter Study (GEMS) in Kenya. A non-dysenteric MSD case was defined as a child with ≥3 loose stools in 24 hrs. and one or more of the following: sunken eyes, skin tenting, intravenous rehydration, or hospitalization, who sought care at a sentinel health center within 7 days of illness onset. Rotavirus antigens in stool samples were detected by ELISA. Demographic and clinical information was collected at enrollment and during a single follow-up home visit at approximately 60 days. We analyzed diarrhea severity using a GEMS 17 point numerical scoring system adapted from the Vesikari score. We used logistic regression to evaluate factors associated with rotavirus infection.
resultsFrom January 31, 2008 to September 30, 2012, among 1,637 (92%) non-dysenteric MSD cases, rotavirus was detected in stools of 245 (15.0%). Rotavirus-positive compared with negative cases were: younger (median age, 8 vs. 13 months; p<0.0001), had more severe illness (median severity score, 9 vs 8; p<0.0001) and had to be hospitalized more frequently (37/245 [15.1%] vs. 134/1,392 [9.6%]), p <0.013). Independent factors associated with rotavirus infection included age 0-11 months old (aOR = 5.29, 95% CI 3.14-8.89) and presenting with vomiting ≥3 times/24hrs (aOR = 2.58, 95% CI [1.91-3.48]). Rotavirus was detected more commonly in warm and dry months than in the cool and rainy months (142/691 [20%] vs 70/673 [10%]) p<0.0001).
conclusionsDiarrhea caused by rotavirus is associated with severe symptoms leading to hospitalization. Consistent with other settings, infants had the greatest burden of disease.
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