Evidence map›Paper›PMID 27494405›Full record

ArticlePLoS neglected tropical diseases2016

Estimating Geographical Variation in the Risk of Zoonotic Plasmodium knowlesi Infection in Countries Eliminating Malaria.

Freya M Shearer, Zhi Huang, Daniel J Weiss, Antoinette Wiebe, Harry S Gibson, Katherine E Battle, David M Pigott, Oliver J Brady, Chaturong Putaporntip, Somchai Jongwutiwes and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 7 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 7 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  4. The Role of Human Behavior inInternational journal of environmental research and public health · 2022
    Pooled it
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  7. Deaths From Plasmodium knowlesi Malaria: Case Series and Systematic Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Pooled it
  8. Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 6 countries.

Freya M ShearerSpatial Ecology & Epidemiology Group, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Zhi HuangMalaria Atlas Project, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Daniel J WeissMalaria Atlas Project, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Antoinette WiebeSpatial Ecology & Epidemiology Group, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Harry S GibsonMalaria Atlas Project, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Katherine E BattleMalaria Atlas Project, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
David M PigottInstitute of Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
Oliver J BradySpatial Ecology & Epidemiology Group, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Chaturong PutaporntipMolecular Biology of Malaria and Opportunistic Parasites Research Unit, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Somchai JongwutiwesMolecular Biology of Malaria and Opportunistic Parasites Research Unit, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Yee Ling LauDepartment of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Magnus ManskeWellcome Trust Sanger Institute, Hinxton, United Kingdom.
Roberto AmatoWellcome Trust Sanger Institute, Hinxton, United Kingdom.
Iqbal R F ElyazarEijkman-Oxford Clinical Research Unit, Jakarta, Indonesia.
Indra VythilingamDepartment of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Samir BhattMalaria Atlas Project, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Peter W GethingMalaria Atlas Project, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Balbir SinghMalaria Research Centre, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia.
Nick GoldingSpatial Ecology & Epidemiology Group, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Simon I HaySpatial Ecology & Epidemiology Group, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.
Catherine L MoyesSpatial Ecology & Epidemiology Group, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-8028-4079
University of Oxford · GBChulalongkorn University · THUniversity of Malaya · MYUniversity of Washington · USCentre for Human Genetics · GBEijkman Institute for Molecular Biology · IDThe University of Melbourne · AUUniversiti Malaysia Sarawak · MYWellcome Sanger Institute · GB

Funding

Medical Research Council K00669XMedical Research Council MR/K010174/1Wellcome Trust 095066Wellcome Trust 098051
6 · The paper itself

Abstract

backgroundInfection by the simian malaria parasite, Plasmodium knowlesi, can lead to severe and fatal disease in humans, and is the most common cause of malaria in parts of Malaysia. Despite being a serious public health concern, the geographical distribution of P. knowlesi malaria risk is poorly understood because the parasite is often misidentified as one of the human malarias. Human cases have been confirmed in at least nine Southeast Asian countries, many of which are making progress towards eliminating the human malarias. Understanding the geographical distribution of P. knowlesi is important for identifying areas where malaria transmission will continue after the human malarias have been eliminated. METHODOLOGY/PRINCIPAL

findingsA total of 439 records of P. knowlesi infections in humans, macaque reservoir and vector species were collated. To predict spatial variation in disease risk, a model was fitted using records from countries where the infection data coverage is high. Predictions were then made throughout Southeast Asia, including regions where infection data are sparse. The resulting map predicts areas of high risk for P. knowlesi infection in a number of countries that are forecast to be malaria-free by 2025 (Malaysia, Cambodia, Thailand and Vietnam) as well as countries projected to be eliminating malaria (Myanmar, Laos, Indonesia and the Philippines). CONCLUSIONS/SIGNIFICANCE: We have produced the first map of P. knowlesi malaria risk, at a fine-scale resolution, to identify priority areas for surveillance based on regions with sparse data and high estimated risk. Our map provides an initial evidence base to better understand the spatial distribution of this disease and its potential wider contribution to malaria incidence. Considering malaria elimination goals, areas for prioritised surveillance are identified.

Indexed as

Disease EradicationAnimalsAsia, SoutheasternCambodiaDisease ReservoirsEpidemiological MonitoringGeographyHumansIncidenceIndonesiaLaosMacacaMalariaMalaysiaMyanmarPhilippines

Identifiers

PMID27494405
PMCPMC4975412
OpenAlexW2497599617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.