ArticlePloS one2016
Variation of DNA Methylome of Zebrafish Cells under Cold Pressure.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Genomic and Epigenomic Influences on Resilience across Scales: Lessons from the Responses of Fish to Environmental Stressors.Integrative and comparative biology · 2024Review
- Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish.Zoological research · 2024Article
- To live or let die? Epigenetic adaptations to climate change-a review.Environmental epigenetics · 2024Review
- Analysis of DNA Methylation Differences during the JIII Formation ofCurrent issues in molecular biology · 2023Article
- Integrated Analysis of DNA Methylome and Transcriptome Reveals Epigenetic Regulation of Cold Tolerance inInternational journal of molecular sciences · 2023Article
- DNA Methylation Variation Is a Possible Mechanism in the Response ofInternational journal of molecular sciences · 2022Article
- Whole genome bisulfite sequencing reveals DNA methylation roles in the adaptive response of wildness training giant pandas to wild environment.Frontiers in genetics · 2022Article
- Cold Acclimation for Enhancing the Cold Tolerance of Zebrafish Cells.Frontiers in physiology · 2021Article
- Chicken cecal DNA methylome alteration in the response to Salmonella enterica serovar Enteritidis inoculation.BMC genomics · 2020Article
- Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish.Frontiers in genetics · 2020Article
- Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells.PloS one · 2020Article
- Epigenetic mechanisms underlying the effects of triptolide and tripchlorolide on the expression of neuroligin-1 in the hippocampus of APP/PS1 transgenic mice.Pharmaceutical biology · 2019Article
- Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?G3 (Bethesda, Md.) · 2019Article
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Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is an essential epigenetic mechanism involved in multiple biological processes. However, the relationship between DNA methylation and cold acclimation remains poorly understood. In this study, Methylated DNA Immunoprecipitation Sequencing (MeDIP-seq) was performed to reveal a genome-wide methylation profile of zebrafish (Danio rerio) embryonic fibroblast cells (ZF4) and its variation under cold pressure. MeDIP-seq assay was conducted with ZF4 cells cultured at appropriate temperature of 28°C and at low temperature of 18°C for 5 (short-term) and 30 (long-term) days, respectively. Our data showed that DNA methylation level of whole genome increased after a short-term cold exposure and decreased after a long-term cold exposure. It is interesting that metabolism of folate pathway is significantly hypomethylated after short-term cold exposure, which is consistent with the increased DNA methylation level. 21% of methylation peaks were significantly altered after cold treatment. About 8% of altered DNA methylation peaks are located in promoter regions, while the majority of them are located in non-coding regions. Methylation of genes involved in multiple cold responsive biological processes were significantly affected, such as anti-oxidant system, apoptosis, development, chromatin modifying and immune system suggesting that those processes are responsive to cold stress through regulation of DNA methylation. Our data indicate the involvement of DNA methylation in cellular response to cold pressure, and put a new insight into the genome-wide epigenetic regulation under cold pressure.
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