ArticlePloS one2016
Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated with Altered Central Executive Network Community Structure during Cognitive Task.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Spatial Entropy of Brain Network Landscapes: A Novel Method to Assess Spatial Disorder in Brain Networks.Human brain mapping · 2026Article
- Leveraging Machine Learning to Advance Alcohol Research: Current Applications, Challenges, and Opportunities.Alcohol research : current reviews · 2026Review
- Abstinence Alters Triple Network Dynamics in Moderate-to-Heavy Drinkers.Human brain mapping · 2025Article
- Spatial entropy of brain network landscapes: a novel method to assess spatial disorder in brain networks.bioRxiv : the preprint server for biology · 2025Article
- Contrast Sensitivity Predicts 30-month Functional Brain Network Integrity in Cognitively Unimpaired Older Adults: the Brain Networks and Mobility Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
- IMOVE: Protocol for a randomized, controlled 2x2 factorial trial of improvisational movement and social engagement interventions in older adults with early Alzheimer's disease.Contemporary clinical trials communications · 2023Article
- Learning Brain Dynamics of Evolving Manifold Functional MRI Data Using Geometric-Attention Neural Network.IEEE transactions on medical imaging · 2022Article
- Uncovering shape signatures of resting-state functional connectivity by geometric deep learning on Riemannian manifold.Human brain mapping · 2022Article
- Altered default mode network associated with pesticide exposure in Latinx children from rural farmworker families.NeuroImage · 2022Article
- Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization.Drug and alcohol dependence · 2022Article
- Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.Brain sciences · 2021Article
- Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder.Brain sciences · 2021Article
- Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study.Brain sciences · 2021Article
- Embedding Functional Brain Networks in Low Dimensional Spaces Using Manifold Learning Techniques.Frontiers in neuroinformatics · 2021Article
- Improvisational Movement to Improve Quality of Life in Older Adults With Early-Stage Dementia: A Pilot Study.Frontiers in sports and active living · 2021Article
- History of Alcohol Consumption and HIV Status Related to Functional Connectivity Differences in the Brain During Working Memory Performance.Current HIV research · 2020Article
- Analysis of brain subnetworks within the context of their whole-brain networks.Human brain mapping · 2019Article
- A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking.Addictive behaviors reports · 2019Article
- Using Low-Dimensional Manifolds to Map Relationships Between Dynamic Brain Networks.Frontiers in human neuroscience · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Older adults today consume more alcohol than previous generations, the majority being social drinkers. The effects of heavy alcohol use on brain functioning closely resemble age-related changes, but it is not known if moderate-heavy alcohol consumption intensifies brain aging. Whether a lifestyle of moderate-heavy alcohol use in older adults increased age-related brain changes was examined. Forty-one older adults (65-80 years) that consumed light (< 2 drinks/week and ≥ 1 drink/month, n = 20) or moderate-heavy (7-21 drinks/week, non-bingers, n = 21) amounts of alcohol were enrolled. Twenty-two young adults (24-35 years) were also enrolled (light, n = 11 and moderate-heavy, n = 11). Functional brain networks based on magnetic resonance imaging data were generated for resting state and during a working memory task. Whole-brain, Central Executive Network (CEN), and Default Mode Network (DMN) connectivity were assessed in light and moderate-heavy alcohol consuming older adults with comparisons to young adults. The older adults had significantly lower whole brain connectivity (global efficiency) and lower regional connectivity (community structure) in the CEN during task and in the DMN at rest. Moderate-heavy older drinkers did not exhibit whole brain connectivity differences compared to the low drinkers. However, decreased CEN connectivity was observed during the task. There were no differences in the DMN connectivity between drinking groups. Taken together, a lifestyle including moderate-heavy alcohol consumption may be associated with further decreases in brain network connectivity within task-related networks in older adults. Further research is required to determine if this decrease is compensatory or an early sign of decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.