Evidence map›Paper›PMID 27494079›Full record

ArticleJournal of psychiatric research2016

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder.

Mohamed Abdulkadir, Jay A Tischfield, Robert A King, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Sebastian F T M de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar and 43 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Investigation of gene-environment interactions in relation to tic severity.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Pooled it
  2. Pooled it
  3. Tourette syndrome.Nature reviews. Disease primers · 2026
    Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Genetic Approaches to Understanding Psychiatric Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017
    Review
  19. Review
  20. Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

53 authors at 20 institutions in 7 countries.

Mohamed AbdulkadirRutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USA; University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands. Electronic address: abdulkadir@dls.rutgers.edu.
Jay A TischfieldRutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USA.
Robert A KingYale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Thomas V FernandezYale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Lawrence W BrownChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Keun-Ah CheonYonsei University College of Medicine, Severance Hospital, Seoul, South Korea.
Barbara J CoffeyIcahn School of Medicine at Mount Sinai, New York, NY, USA; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Sebastian F T M de BruijnHaga Teaching Hospital, Department of Neurology, The Hague, The Netherlands.
Lonneke ElzermanYulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands.
Blanca Garcia-DelgarDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain.
Donald L GilbertCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Dorothy E GriceIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Julie HagstrømChild and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, Denmark.
Tammy HedderlyEvelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UK.
Isobel HeymanGreat Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UK.
Hyun Ju HongHallym University Sacred Heart Hospital, Anyang, South Korea.
Chaim HuyserDe Bascule, AMC Department of Child and Adolescent Psychiatry, Amsterdam, The Netherlands.
Laura Ibanez-GomezIcahn School of Medicine at Mount Sinai, New York, NY, USA; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Young Key KimYonsei Bom Clinic, South Korea.
Young-Shin KimDepartment of Psychiatry, University of California, San Francisco, USA.
Yun-Joo KohKorea Institute for Children's Social Development, Seoul, South Korea.
Sodahm KookMyongJi Hospital, Koyang, South Korea.
Samuel KupermanUniversity of Iowa Carver College of Medicine, Iowa City, IA, USA.
Andreas LamerzTriversum, Center for Child and Adolescent Psychiatry, Alkmaar, The Netherlands.
Bennett LeventhalDepartment of Psychiatry, University of California, San Francisco, USA.
Andrea G LudolphUniversity of Ulm, Department of Child and Adolescent Psychiatry and Psychotherapy, Ulm, Germany.
Marcos Madruga-GarridoSección de Neuropediatría, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Athanasios MarasYulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
Marieke D MesschendorpUniversity of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands.
Pablo MirUnidad de Trastornos del Movimiento, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Astrid MorerDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIPABS) and Centro de Investigacion en Red de Salud Mental (CIBERSAM), Spain.
Alexander MünchauInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Tara L MurphyGreat Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UK.
Thaïra J C OpenneerUniversity of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands.
Kerstin J PlessenChild and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, Denmark.
Judith J G RathHaga Teaching Hospital, Department of Neurology, The Hague, The Netherlands.
Veit RoessnerDepartment of Child and Adolescent Psychiatry, TU Dresden, Germany.
Odette FründtUniversity Hospital Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Eun-Young ShinYonsei University College of Medicine, Severance Hospital, Seoul, South Korea.
Deborah A SivalUniversity of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, The Netherlands.
Dong-Ho SongYonsei University College of Medicine, Severance Hospital, Seoul, South Korea.
Jungeun SongNational Health Insurance Service Ilsan Hospital, Goyang-si, South Korea.
Anne-Marie StolteAccare, Child and Adolescent Psychiatry, Groningen, The Netherlands.
Jennifer TübingInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Els van den BanYouth Division, Altrecht, Institute for Mental Health, Utrecht, The Netherlands.
Frank VisscherAdmiraal De Ruyter Ziekenhuis, Department of Neurology, Goes, The Netherlands.
Sina WandererDepartment of Child and Adolescent Psychiatry, TU Dresden, Germany.
Martin WoodsEvelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UK.
Samuel H ZinnerUniversity of Washington, Department of Pediatrics, Seattle, WA, USA.
Matthew W StateDepartment of Psychiatry, University of California, San Francisco, USA.
Gary A HeimanRutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USA.
Pieter J HoekstraUniversity of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands.
Andrea DietrichUniversity of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of California, San Francisco · USHaga Hospital · NLIcahn School of Medicine at Mount Sinai · USRutgers, The State University of New Jersey · USSeverance Hospital · KRTechnische Universität Dresden · DEUniversity College London · GBUniversity of Lübeck · DEYale University · USAccare · NLAdmiraal De Ruyter Ziekenhuis · NLAltrecht GGZ · NLCapital Region of Denmark · DKChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USDe Bascule · NLEvelina London Children's Healthcare · GBHallym University Sacred Heart Hospital · KRHospital Universitari de Vic · ES

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
2/8-Collaborative genomic studies of Tourette DisorderR01MH092289 · NIMH · YALE UNIVERSITY · PI STATE, MATTHEW W. · 2011 to 2013
$898k
Genomic Investigations of Tourette's DisorderK08MH099424 · NIMH · YALE UNIVERSITY · PI FERNANDEZ, THOMAS V · 2012 to 2015
$718k
1/8-Collaborative genomic studies of Tourette DisorderR01MH092293 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI HEIMAN, GARY A., TISCHFIELD, JAY ARNOLD · 2011 to 2013
$510k
Collaborative Genomic Studies of Tourette Disorder SupplementR01MH115961 · NIMH · UNIVERSITY OF IOWA · PI KUPERMAN, SAMUEL · 2018 to 2022
$475k
6/7-Collaborative genomic studies of Tourette Disorder.R01MH115993 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI ZINNER, SAMUEL HAMILTON · 2018 to 2022
$369k
8/8-Collaborative Genomic Studies of Tourette DisorderR01MH092292 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COFFEY, BARBARA JANE, LEVENTHAL, BENNETT L. · 2011 to 2013
$280k
3/8-Collaborative Genomic Studies of Tourette DisorderR01MH092290 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BROWN, LAWRENCE W · 2011 to 2013
$248k
6/8-Collaborative genomic studies of Tourette DisorderR01MH092516 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GRICE, DOROTHY E · 2011 to 2013
$240k
4/8-Collaborative genomic studies of Tourette DisorderR01MH092520 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI GILBERT, DONALD L · 2011 to 2013
$226k
5/8-Collaborative Genomic Studies of Tourette DisorderR01MH092291 · NIMH · UNIVERSITY OF IOWA · PI KUPERMAN, SAMUEL · 2011 to 2013
$223k
7/8-Collaborative genomic studies of Tourette DisorderR01MH092513 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI ZINNER, SAMUEL HAMILTON · 2011 to 2013
$212k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K08 MH099424NIMH NIH HHS R01 MH092289NIMH NIH HHS R01 MH092290NIMH NIH HHS R01 MH092291NIMH NIH HHS R01 MH092292NIMH NIH HHS R01 MH092293NIMH NIH HHS R01 MH092513NIMH NIH HHS R01 MH092516NIMH NIH HHS R01 MH092520NIMH NIH HHS R01 MH115961NIMH NIH HHS R01 MH115993
6 · The paper itself

Abstract

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsAttention Deficit Disorder with HyperactivityCase-Control StudiesChildChild, PreschoolEuropeFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderParent-Child RelationsAttention-deficit hyperactivity disorderDeliveryObsessive-compulsive disorderPregnancyPrenatalTourette syndrome

Identifiers

PMID27494079
PMCPMC5026935
OpenAlexW2489582260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.