Evidence map›Paper›PMID 27493999›Full record

Article... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics2016

Integration of Multi-Modal Biomedical Data to Predict Cancer Grade and Patient Survival.

John H Phan, Ryan Hoffman, Sonal Kothari, Po-Yen Wu, May D Wang

Abstract read
In one paragraph

Article in ... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. MoNETA: MultiOmics Network Embedding for SubType Analysis.NAR genomics and bioinformatics · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John H PhanDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
Ryan HoffmanDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
Sonal KothariDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
Po-Yen WuSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.
May D WangDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.

Funding

Tissue and Animal UseU54CA119338 · NCI · EMORY UNIVERSITY · PI SIMONS, JONATHAN W. · 2005 to 2009
$18.4M
A Computational Biology and Predictive Health Genomics Training Program at GTT32GM105490 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GIBSON, GREGORY C · 2014 to 2018
$901k
NCI NIH HHS U54 CA119338NIGMS NIH HHS T32 GM105490
6 · The paper itself

Abstract

The Big Data era in Biomedical research has resulted in large-cohort data repositories such as The Cancer Genome Atlas (TCGA). These repositories routinely contain hundreds of matched patient samples for genomic, proteomic, imaging, and clinical data modalities, enabling holistic and multi-modal integrative analysis of human disease. Using TCGA renal and ovarian cancer data, we conducted a novel investigation of multi-modal data integration by combining histopathological image and RNA-seq data. We compared the performances of two integrative prediction methods: majority vote and stacked generalization. Results indicate that integration of multiple data modalities improves prediction of cancer grade and outcome. Specifically, stacked generalization, a method that integrates multiple data modalities to produce a single prediction result, outperforms both single-data-modality prediction and majority vote. Moreover, stacked generalization reveals the contribution of each data modality (and specific features within each data modality) to the final prediction result and may provide biological insights to explain prediction performance.

Identifiers

PMID27493999
PMCPMC4969000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.