ArticleGlobal pediatric health2016
The Effectiveness and Safety of a Homeopathic Medicinal Product in Pediatric Upper Respiratory Tract Infections With Fever: A Randomized Controlled Trial.
Article in Global pediatric health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05819190 (Efficacy and Safety of Healsea® Hypertonic Nasal Spray 2.7% in the Treatment of Acute Infectious Rhinitis in Adults), which is not on this map. Cited by 8 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Healsea® Hypertonic Nasal Spray 2.7% in the Treatment of Acute Infectious Rhinitis in Adults
Who cites it
8 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.The Cochrane database of systematic reviews · 2022Pooled it
- Symptomatic fever management in children: A systematic review of national and international guidelines.PloS one · 2021Pooled it
- Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.The Cochrane database of systematic reviews · 2018Pooled it
- Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.The Cochrane database of systematic reviews · 2018Pooled it
- Phytotherapeutic, Homeopathic Interventions and Bee Products for Pediatric Infections: A Scoping Review.Nutrients · 2025Article
- Prevention of recurrent respiratory infections : Inter-society Consensus.Italian journal of pediatrics · 2021Article
- Cost-effectiveness analysis for SilAtro-5-90 adjuvant treatment in the management of recurrent tonsillitis, compared with usual care only.Cost effectiveness and resource allocation : C/E · 2021Article
- Homeopathy Use in the United States and Implications for Public Health: A Review.Homeopathy : the journal of the Faculty of Homeopathy · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the clinical effectiveness of a homeopathic add-on therapy in a pediatric subpopulation with upper respiratory tract infections (URTI) in a randomized, controlled, multinational clinical trial. Patients received either on-demand symptomatic standard treatment (ST-group) or the same ST plus a homeopathic medication (Influcid; IFC-group) for 7 days. Outcome assessment was based on symptom and fever resolution and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21). A total of 261 pediatric (<12 years) patients (130 IFC-group; 131 ST-group) were recruited in Germany and the Ukraine. The IFC-group used less symptomatic medication, symptoms resolved significantly earlier (P = .0001), had higher proportions of fever-free children from day 3 onwards, and the WURSS-assessed global disease severity was significantly less (P < .0001) during the entire URTI episode. One adverse event (vomiting) was possibly related to IFC. IFC as add-on treatment in pediatric URTI reduced global disease severity, shortened symptom resolution, and was safe in use.
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Registered trials
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