ArticleEuropean thyroid journal2016
Obesity Does Not Modify the Risk of Differentiated Thyroid Cancer in a Cytological Series of Thyroid Nodules.
Article in European thyroid journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Association between the Chinese visceral adiposity index and thyroid nodule risk: a retrospective analysis of cross-sectional, case-control, and cohort studies.BMC endocrine disorders · 2026Article
- Higher Body Mass Index Shows No Evidence of Association with Histopathologic Markers of Aggressiveness in Early-Stage Papillary Thyroid Carcinoma.Biomedicines · 2025Article
- Adiposity Is Associated with a Higher Risk of Thyroid Malignancy in Patients with Hashimoto's Thyroiditis.Diagnostics (Basel, Switzerland) · 2025Article
- Adiposity is associated with a higher number of thyroid nodules and worse fine-needle aspiration outcomes.European thyroid journal · 2025Article
- Early-onset and later-onset cancer: trends, risk factors, and prevention in Northern China.Science China. Life sciences · 2024Article
- Subclinical Hypothyroidism in Patients with Obesity and Metabolic Syndrome: A Narrative Review.Nutrients · 2023Review
- Weighty Matters: The Obesity-Thyroid Nodule Connection Unveiling the Impact of Obesity on Thyroid Cancer Risk.Medicina (Kaunas, Lithuania) · 2023Article
- Thyroid Nodules and Obesity.Life (Basel, Switzerland) · 2023Review
- Point of Care Measurement of Body Mass Index and Thyroid Nodule Malignancy Risk Assessment.Frontiers in endocrinology · 2022Article
- Review
- Morbid Obesity and Thyroid Cancer Rate. A Review of Literature.Journal of clinical medicine · 2021Review
- Influence of body mass index on the clinicopathological features of 13,995 papillary thyroid tumors.Journal of endocrinological investigation · 2020Article
- Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study.The Journal of clinical endocrinology and metabolism · 2020Article
- Observational
- Lack of association between obesity and aggressiveness of differentiated thyroid cancer.Journal of endocrinological investigation · 2019Article
- The obesity paradox in cancer: clinical insights and perspectives.Eating and weight disorders : EWD · 2018Review
- The impact of BMI on clinical progress, response to treatment, and disease course in patients with differentiated thyroid cancer.PloS one · 2018Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA possible impact of obesity on the risk of thyroid cancer has been postulated in some studies, but it remains controversial.
objectiveTo investigate the association between obesity and differentiated thyroid carcinoma in a population of unselected patients subjected to fine-needle aspiration cytology (FNAC) for thyroid nodules.
methodsWe retrospectively evaluated the results of FNAC of thyroid nodules in 4,849 patients (3,809 females and 1,040 males; mean age 55.9 ± 14.1 years). Patients were stratified according to their body mass index (BMI). There were 1,876 (38.7%) normal-weight patients (BMI 18-24.9), 1,758 (36.2%) overweight (BMI 25-29.9), 662 (13.7%) grade 1 obese (BMI 30-34.9), 310 (6.4%) grade 2 obese (BMI 35-39.9) and 243 (5.0%) grade 3 obese (BMI >40).
resultsThe prevalence of suspicious or malignant nodules (Thy4/Thy5) did not differ across the 5 BMI groups, i.e. it was 6.8% in normal-weight patients, 6.3% in overweight patients, 6.3% in grade 1 obese patients, 4.0% in grade 2 obese patients and 4.2% in grade 3 obese patients (p = 0.29). The prevalence of Thy4/Thy5 nodules did not differ when males and females were evaluated separately (p = 0.22 and p = 0.12, respectively). A significant, lower rate of Thy4/5 cytology was observed in female patients with grade 2-3 obesity (odds ratio 0.51; 95% confidence interval 0.284-0.920; p = 0.009).
conclusionsThe results of this study, in a retrospective series of patients with thyroid nodules, do not confirm previous findings reporting an association between obesity and differentiated thyroid carcinoma. Thus, obese patients with nodular thyroid disease should be managed the same as normal-weight patients.
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