ArticleJournal of cachexia, sarcopenia and muscle2016
White adipose tissue cells and the progression of cachexia: inflammatory pathways.
Article in Journal of cachexia, sarcopenia and muscle, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.Nature cancer · 2026Article
- Cachexia causes time-dependent activation of the inflammasome in the liver.Journal of cachexia, sarcopenia and muscle · 2023Article
- Review
- MicroRNAs: Novel players in the diagnosis and treatment of cancer cachexia (Review).Experimental and therapeutic medicine · 2022Review
- The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy.Journal of biomedical science · 2022Review
- Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives.Translational oncology · 2021Review
- Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia.Frontiers in immunology · 2021Article
- Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Review
- Muscle alterations in the development and progression of cancer-induced muscle atrophy: a review.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- Adipogenesis in Different Body Depots and Tumor Development.Frontiers in cell and developmental biology · 2020Review
- Metastasis and cachexia: alongside in clinics, but not so in animal models.Journal of cachexia, sarcopenia and muscle · 2019Review
- Association between ANGPTL-4 and the proinflammatory process in cancer cachexia patients.Oncotarget · 2019Article
- Muscle metabolism and atrophy: let's talk about sex.Biology of sex differences · 2019Review
- Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle.Cancers · 2019Article
- Pseudomonas aeruginosa-derived pyocyanin reduces adipocyte differentiation, body weight, and fat mass as mechanisms contributing to septic cachexia.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Article
- A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells.PloS one · 2019Article
- Contemporary publication patterns in the Journal of Cachexia, Sarcopenia and Muscle by type and sub-speciality: facts and numbers.Journal of cachexia, sarcopenia and muscle · 2018Article
- Chemotherapy-induced muscle wasting: an update.European journal of translational myology · 2018Article
- Oodles of opportunities: the Journal of Cachexia, Sarcopenia and Muscle in 2017.Journal of cachexia, sarcopenia and muscle · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCachexia is a systemic syndrome leading to body wasting, systemic inflammation, and to metabolic chaos. It is a progressive condition, and little is known about its dynamics. Detection of the early signs of the disease may lead to the attenuation of the associated symptoms. The white adipose tissue is an organ with endocrine functions, capable of synthesising and secreting a plethora of proteins, including cytokines, chemokines, and adipokines. It is well established that different adipose tissue depots demonstrate heterogeneous responses to physiological and pathological stimuli. The present study aimed at providing insight into adipocyte involvement in inflammation along the progression of cachexia.
methodsEight-weeks-old male rats were subcutaneously inoculated with a Walker 256 carcinosarcoma cell suspension (2 × 10(7) cells in 1.0 mL; tumour-bearing, T) or Phosphate-buffered saline (control, C). The retroperitoneal, epididymal, and mesenteric adipose pads were excised on Days 0, 7, and 14 post-tumour cell injection, and the adipocytes were isolated.
resultsMesenteric and epididymal adipocytes showed up-regulation of IL-1β protein expression and activation of the inflammasome pathway, contributing for whole tissue inflammation. The stromal vascular fraction of the retroperitoneal adipose tissue, on the other hand, seems to be the major contributor for the inflammation in this specific pad.
conclusionAdipocytes seem to play a relevant role in the establishment of white adipose tissue inflammation, through the activation of the NF-κB and inflammasome pathways. In epididymal adipocytes, induction of the inflammasome may be detected already on Day 7 post-tumour cell inoculation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.