ArticleBiophysics and physicobiology2015
Liquid-theory analogy of direct-coupling analysis of multiple-sequence alignment and its implications for protein structure prediction.
Article in Biophysics and physicobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Monte Carlo simulation of a statistical mechanical model of multiple protein sequence alignment.Biophysics and physicobiology · 2017Article
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Abstract
The direct-coupling analysis is a powerful method for protein contact prediction, and enables us to extract "direct" correlations between distant sites that are latent in "indirect" correlations observed in a protein multiple-sequence alignment. I show that the direct correlation can be obtained by using a formulation analogous to the Ornstein-Zernike integral equation in liquid theory. This formulation intuitively illustrates how the indirect or apparent correlation arises from an infinite series of direct correlations, and provides interesting insights into protein structure prediction.
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