Evidence map›Paper›PMID 27493831›Full record

ArticleAging and disease2016

Ischemia-induced Angiogenesis is Attenuated in Aged Rats.

Yaohui Tang, Liuqing Wang, Jixian Wang, Xiaojie Lin, Yongting Wang, Kunlin Jin, Guo-Yuan Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Vascular Aging in Ischemic Stroke.Journal of the American Heart Association · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yaohui Tang1Neuroscience and Neuroengineering Center, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China; 2Department of Orthopaedic surgery, School of medicine, Stanford University, CA 94305, USA.
Liuqing Wang3Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang, 325000, China.
Jixian Wang5Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200030, China.
Xiaojie Lin1Neuroscience and Neuroengineering Center, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
Yongting Wang1Neuroscience and Neuroengineering Center, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
Kunlin Jin3Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang, 325000, China; 4Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, TX 76203, USA.
Guo-Yuan Yang1Neuroscience and Neuroengineering Center, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China; 5Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200030, China.
Shanghai Jiao Tong University · CNFirst Affiliated Hospital of Wenzhou Medical University · CNStanford University · USUniversity of North Texas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To study whether focal angiogenesis is induced in aged rodents after permanent distal middle cerebral artery occlusion (MCAO), young adult (3-month-old) and aged (24-month-old) Fisher 344 rats underwent MCAO and sacrificed up to two months after MCAO. Immunohistochemistry and synchrotron radiation microangiography were performed to examine the number of newly formed blood vessels in both young adult and aged rats post-ischemia. We found that the number of capillaries and small arteries in aged brain was the same as young adult brain. In addition, we found that after MCAO, the number of blood vessels in the peri-infarct region of ipsilateral hemisphere in aged ischemic rats was significantly increased compared to the aged sham rats (p<0.05). We also confirmed that ischemia-induced focal angiogenesis occurred in young adult rat brain while the blood vessel density in young adult ischemic brain was significantly higher than that in the aged ischemic brain (p<0.05). Our data suggests that focal angiogenesis in aged rat brain can be induced in response to ischemic brain injury, and that aging impedes brain repairing and remodeling after ischemic stroke, possible due to the limited response of angiogenesis.

Indexed as

agingangiogenesisbrainfocal cerebral ischemiarat

Identifiers

PMID27493831
PMCPMC4963187
OpenAlexW2481583587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.