Evidence map›Paper›PMID 27493808›Full record

ReviewArab journal of urology2016

Innovative trends and perspectives for erectile dysfunction treatment: A systematic review.

Ezzat A Ismail, Ahmed I El-Sakka

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Arab journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 49 citations in OpenAlex.

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  8. Nutritional aphrodisiacs: Biochemistry and Pharmacology.Current research in food science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ezzat A IsmailDepartment of Urology, Suez Canal University, Ismailia, Egypt.
Ahmed I El-SakkaDepartment of Urology, Suez Canal University, Ismailia, Egypt.
Suez Canal University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo review contemporary knowledge concerning the innovative trends and perspectives in the treatment of erectile dysfunction (ED).

methodsMedline was reviewed for English-language journal articles between January 2000 and March 2016, using the terms 'erectile dysfunction treatments', 'new trends' and 'perspectives'. In all, 114 original articles and 16 review articles were found to be relevant. Of the 76 cited papers that met the inclusion criteria, 51 papers had level of evidence of 1a-2b, whilst 25 had level of evidence of 3-4. Criteria included all pertinent review articles, randomised controlled trials with tight methodological design, cohort studies, and retrospective analyses. We also manually reviewed references from selected articles.

resultsSeveral interesting studies have addressed novel phosphodiesterase type 5 inhibitors (PDE5Is), orodispersible tablets, their recent chronic use, and combination with other agents. A few controlled studies have addressed herbal medicine as a sole or additional treatment for ED. Experimental studies and exciting review papers have addressed stem cells as novel players in the field of ED treatment. Other recent articles have revised the current status of low-intensity extracorporeal shockwave therapy in the field of ED. A few articles without long-term data have addressed new technologies that included: external penile support devices, penile vibrators, tissue engineering, nanotechnology, and endovascular tools for ED treatment.

conclusionsThe current treatment of ED is still far from ideal. We expect to see new drugs and technologies that may revolutionise ED treatment, especially in complex cases.

Indexed as

ADSCs, adipose tissue-derived stem cellscGMP, cyclic guanosine monophosphatecNOS, constitutive nitric oxide synthaseED, erectile dysfunctionErectile dysfunctionFDA, USA Food and Drug AdministrationHerbal treatment(hUCB-)MSCs, (human umbilical cord blood) mesenchymal stem cellsICI, intracavernosal injectionLI-ESWT, low-intensity extracorporeal shockwave therapyNO, nitric oxidePDE5 inhibitorsPDE5Is, phosphodiesterase type 5 inhibitorsRP, radical prostatectomySC, stem cellsGC, soluble guanylate cyclaseShockwave therapyStem cellsVED, vacuum erectile deviceVEGF, vascular endothelial growth factor

Identifiers

PMID27493808
PMCPMC4963167
OpenAlexW2399211445

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.