ReviewTherapeutic advances in drug safety2016
Medication-overuse headache: a perspective review.
Review in Therapeutic advances in drug safety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The global prevalence of headache disorders of public-health importance: a meta-analysis of population-based individual participant data from 41,614 adults from 17 countries.The journal of headache and pain · 2025Pooled it
- Efficacy and safety of eptinezumab in adults with chronic migraine and medication-overuse headache who also received patient education: 24-week results of the randomized RESOLUTION trial.The journal of headache and pain · 2026Trial
- Eptinezumab With Patient Education for Chronic Migraine and Medication-Overuse Headache: The Randomized, Placebo-Controlled RESOLUTION Trial.Neurology · 2026Trial
- Article
- Medication overuse headache from a tertiary headache center in Egypt: real-world insights.The journal of headache and pain · 2026Article
- Assessing Self-medication Practices Among Healthcare Providers With Migraine in Saudi Arabia.Brain and behavior · 2025Article
- Clinical Features and Treatment Outcomes of Medication Overuse Headache in Older Patients: Insights from a Nationwide Prospective Registry.Journal of clinical medicine · 2025Article
- The burden of headache disorders among adults in Peru: national estimates and a health-care needs assessment from a population-based door-to-door survey.The journal of headache and pain · 2024Article
- Headache prevalence and demographic associations in the Delhi and National Capital Region of India: estimates from a cross-sectional nationwide population-based study.The journal of headache and pain · 2024Article
- The burden of headache and a health-care needs assessment in the adult population of Mali: a cross-sectional population-based study.The journal of headache and pain · 2024Article
- The prevalence and demographic associations of headache in the adult population of Benin: a cross-sectional population-based study.The journal of headache and pain · 2024Article
- A Descriptive Review of Medication-Overuse Headache: From Pathophysiology to the Comorbidities.Brain sciences · 2023Review
- Breaking the cycle: unraveling the diagnostic, pathophysiological and treatment challenges of refractory migraine.Frontiers in neurology · 2023Review
- Medication overuse headache: a review of current evidence and management strategies.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Article
- Effectiveness of ketogenic diet in treatment of patients with refractory chronic migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Economic burden of medication-overuse headache in Iran: direct and indirect costs.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Headache and Neuroimaging: Why We Continue to Do It.AJNR. American journal of neuroradiology · 2020Review
- Current Approach to Medication Overuse Headache.Noro psikiyatri arsivi · 2019Article
- Eighty years of Medication-Overuse Headache: what about Medication-Overuse Backpain?Journal of neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medication-overuse headache (MOH) is a debilitating condition in which frequent and prolonged use of medication for the acute treatment of pain results in the worsening of the headache. The purpose of this paper is to review the most recent literature on MOH and discuss future avenues for research. MOH accounts for a substantial share of the global burden of disease. Prevalence is often reported as 1-2% but can be as high as 7% overall, with higher proportions among women and in those with a low socioeconomic position. Management consists of withdrawing pain medication, focusing on prophylactic and nonmedical treatments, and limiting acute symptomatic medication. Stress reduction and lifestyle interventions may support the change towards rational pain medication use. Support, follow up, and education are needed to help patients through the detoxification period. There is fertile ground for research in MOH epidemiology, pathophysiology, and neuroimaging. Randomized and long-term follow-up studies on MOH treatment protocols are needed. Further focused research could be of major importance for global health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.