ReviewTherapeutic advances in musculoskeletal disease2016
Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications.
Review in Therapeutic advances in musculoskeletal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Mapping the citation network on vitamin D research in Australia: a data-driven approach.Frontiers in medicine · 2023Pooled it
- Pooled it
- How 25(OH)D Levels during Pregnancy Affect Prevalence of Autism in Children: Systematic Review.Nutrients · 2020Pooled it
- Pooled it
- The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial.BMC pregnancy and childbirth · 2019Trial
- Low serum vitamin D levels are associated with neonatal indirect hyperbilirubinemia and prolonged phototherapy duration: a retrospective case-control study.BMC pediatrics · 2026Article
- Does Vitamin D-Binding Protein Predict Response to Vitamin D Supplementation in Term and Preterm Newborns? A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Maternal vitamin D and genetic variants determine cord blood vitamin D levels in newborn.Pediatric research · 2026Article
- The metabolic implications of maternal exercise: effects on pregnant women and their offspring.Frontiers in nutrition · 2026Review
- Beyond deficiency prevention: meteorological determinants and nonlinear associations of maternal vitamins D, A, and E with perinatal outcomes in 10,824 Chinese pregnancies.Frontiers in nutrition · 2026Article
- Seasonal and Environmental Determinants of Maternal and Neonatal Vitamin D Status: A Cross-Sectional Observational Cohort Study in Urban Greece.Healthcare (Basel, Switzerland) · 2025Article
- Potential application of vitamins to combat biofilm-mediated drug resistance by pathogenic bacteria.Future microbiology · 2025Review
- Vitamin D status among pregnant women of North Macedonia: Assessing deficiency rates and associated risks factors.Journal of medical biochemistry · 2025Article
- Prenatal Determinants of Maternal 25(OH)D Levels at Delivery: The Role of Diet and Supplement Use in a Cross-Sectional Study in Greece.Medicina (Kaunas, Lithuania) · 2025Article
- Determining the Relationship Between Maternal and Neonatal Vitamin D Serum Levels in Term Infants With and Without Sepsis.Journal of family & reproductive health · 2025Article
- From cultural dispositions to biological dimensions: a narrative review on the synergy between oral health and vitamin D through the lens of Indian habitus.Frontiers in oral health · 2025Review
- Vitamin D Deficiency and Maternal Diseases as Risk Factors for the Development of Macrosomia in Newborns.Children (Basel, Switzerland) · 2024Article
- Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infection.Scientific reports · 2024Article
- Vitamin D Metabolites in Mother-Infant Dyads and Associated Clinical Outcomes in a Population of Nigerian Women.Nutrients · 2024Article
- Gestational vitamin D and offspring fracture risk: do associations persist into mid adolescence?European journal of clinical nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low maternal vitamin D levels during pregnancy have been associated with a plethora of adverse neonatal outcomes, including small for gestational age and preterm births, detrimental effect on offspring bone and teeth development, and risk of infectious diseases. Although most observational studies indicate a significant linear relationship between maternal 25-hydroxyvitamin D and the above outcomes, some randomized controlled trials to date are inconclusive, mostly due to differences in study design and supplementation regimen. The currently available results indicate that vitamin D supplementation during pregnancy reduces the risk of preterm birth, low birth weight, dental caries of infancy, and neonatal infectious diseases such as respiratory infections and sepsis. This narrative review aims to summarize available trial results regarding the effect of low maternal vitamin D levels during pregnancy, in conjunction with neonatal outcomes on the field, with a discourse on the appropriate clinical approach of this important issue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.