ArticleBiotechnology for biofuels2016
Dynamic flux balance modeling to increase the production of high-value compounds in green microalgae.
Article in Biotechnology for biofuels, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- dAMN: a genome-scale neural-mechanistic hybrid model to predict bacterial growth dynamics.Bioinformatics (Oxford, England) · 2026Article
- Microalgae-Driven Circular Agriculture: System Integration, Nutrient Recovery, and AI-Assisted Optimization.Microorganisms · 2026Review
- Proteomics and constraint-based modelling reveal enzyme kinetic properties of Chlamydomonas reinhardtii on a genome scale.Nature communications · 2023Article
- Systems-level analysis of the plasticity of the maize metabolic network reveals novel hypotheses in the nitrogen-use efficiency of maize roots.Journal of experimental botany · 2022Article
- Combination of Genome-Scale Models and Bioreactor Dynamics to Optimize the Production of Commodity Chemicals.Frontiers in molecular biosciences · 2022Article
- The paradoxes hidden behind the Droop model highlighted by a metabolic approach.Frontiers in plant science · 2022Article
- Dynamic Flux Balance Analysis to Evaluate the Strain Production Performance on Shikimic Acid Production inMetabolites · 2020Article
- Reconstruction and analysis of a carbon-core metabolic network for Dunaliella salina.BMC bioinformatics · 2020Article
- Utilizing genome-scale models to optimize nutrient supply for sustained algal growth and lipid productivity.NPJ systems biology and applications · 2019Article
- A Review of Dynamic Modeling Approaches and Their Application in Computational Strain Optimization for Metabolic Engineering.Frontiers in microbiology · 2018Review
- A Dynamic Multi-Tissue Flux Balance Model Captures Carbon and Nitrogen Metabolism and Optimal Resource Partitioning During Arabidopsis Growth.Frontiers in plant science · 2018Article
- Editorial: chemicals and bioproducts from biomass.Biotechnology for biofuels · 2016Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPhotosynthetic organisms can be used for renewable and sustainable production of fuels and high-value compounds from natural resources. Costs for design and operation of large-scale algae cultivation systems can be reduced if data from laboratory scale cultivations are combined with detailed mathematical models to evaluate and optimize the process.
resultsIn this work we present a flexible modeling formulation for accumulation of high-value storage molecules in microalgae that provides quantitative predictions under various light and nutrient conditions. The modeling approach is based on dynamic flux balance analysis (DFBA) and includes regulatory models to predict the accumulation of pigment molecules. The accuracy of the model predictions is validated through independent experimental data followed by a subsequent model-based fed-batch optimization. In our experimentally validated fed-batch optimization study we increase biomass and [Formula: see text]-carotene density by factors of about 2.5 and 2.1, respectively.
conclusionsThe analysis shows that a model-based approach can be used to develop and significantly improve biotechnological processes for biofuels and pigments.
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