ReviewFrontiers in physiology2016
What Is the Arrhythmic Substrate in Viral Myocarditis? Insights from Clinical and Animal Studies.
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 77 citations in OpenAlex.
- Arrhythmic Burden After Myocarditis: From Molecular Mechanisms to Therapeutic Strategies.European cardiology · 2026Review
- COVID-19 and Cardiac Arrhythmias: Lesson Learned and Dilemmas.Journal of clinical medicine · 2024Article
- "When," "Where," and "How" of SARS-CoV-2 Infection Affects the Human Cardiovascular System: A Narrative Review.Balkan medical journal · 2024Review
- Cardiac Complications and COVID-19: A Review of Life-threatening Co-morbidities.Current cardiology reviews · 2024Review
- Biological Modification of Arrhythmogenic Substrates by Cell-Free Therapeutics.Heart, lung & circulation · 2023Review
- Advanced Temporally-Spatially Precise Technologies for On-Demand Neurological Disorder Intervention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Role of POCUS in the Management of New-onset Tachyarrhythmia in the Setting of SARS-CoV-2: A Case Report.Journal of community hospital internal medicine perspectives · 2023Article
- Incidence of arrhythmias in COVID-19 patients with double mutant strain of SARS-CoV-2 virus: A tertiary care experience.Global cardiology science & practice · 2022Article
- Cardiovascular Complications of Viral Respiratory Infections and COVID-19.Biomedicines · 2022Review
- Clinical Management of New-Onset Atrial Fibrillation in COVID-19 Patients Referred to a Tertiary Cardiac Arrhythmia Center after Hospital Discharge.Journal of clinical medicine · 2022Article
- Effects of COVID-19 on Arrhythmia.Journal of cardiovascular development and disease · 2022Review
- COVID-19: cardiovascular manifestations-a review of the cardiac effects.Journal of geriatric cardiology : JGC · 2022Article
- Prevalence, Management, and Outcome of Atrial Fibrillation and Other Supraventricular Arrhythmias in COVID-19 Patients.Cardiac electrophysiology clinics · 2022Review
- Cardiac Evaluation in Children with Multisystem Inflammatory Syndrome Associated with SARS-CoV-2.Sisli Etfal Hastanesi tip bulteni · 2022Article
- COVID-19: The Impact on Cardiovascular System.Biomedicines · 2021Review
- QTc Dispersion Predicts Prognosis in COVID-19 Disease.Korean circulation journal · 2021Article
- Role of the Renin-Angiotensin-Aldosterone and Kinin-Kallikrein Systems in the Cardiovascular Complications of COVID-19 and Long COVID.International journal of molecular sciences · 2021Review
- Use of the new Lake Louise Criteria improves CMR detection of atypical forms of acute myocarditis.The international journal of cardiovascular imaging · 2021Article
- Infanticide vs. inherited cardiac arrhythmias.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- Lone Atrial Flutter in Children and Adolescents: Is It Really "Lone"?Pediatric cardiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sudden cardiac death (SCD) remains an unsolved problem in the twenty-first century. It is often due to rapid onset, ventricular arrhythmias caused by a number of different clinical conditions. A proportion of SCD patients have identifiable diseases such as cardiomyopathies, but for others, the causes are unknown. Viral myocarditis is becoming increasingly recognized as a contributor to unexplained mortality, and is thought to be a major cause of SCD in the first two decades of life. Myocardial inflammation, ion channel dysfunction, electrophysiological, and structural remodeling may play important roles in generating life-threatening arrhythmias. The aim of this review article is to examine the electrophysiology of action potential conduction and repolarization and the mechanisms by which their derangements lead to triggered and reentrant arrhythmogenesis. By synthesizing experimental evidence from pre-clinical and clinical studies, a framework of how host (inflammation), and viral (altered cellular signaling) factors can induce ion electrophysiological and structural remodeling is illustrated. Current pharmacological options are mainly supportive, which may be accompanied by mechanical circulatory support. Heart transplantation is the only curative option in the worst case scenario. Future strategies for the management of viral myocarditis are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.