ArticleBiophysics (Nagoya-shi, Japan)2015
The activity of isolated snail neurons controlling locomotion is affected by glucose.
Article in Biophysics (Nagoya-shi, Japan), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Effect of Air Exposure-Induced Hypoxia on Neurotransmitters and Neurotransmission Enzymes in Ganglia of the ScallopInternational journal of molecular sciences · 2022Article
- Exercise and the Brain: Lessons From Invertebrate Studies.Frontiers in behavioral neuroscience · 2022Review
- Mechanism behind the neuronal ephaptic coupling during synchronizing by specific brain-triggered wave as neuronal motor toolkit.Scientific reports · 2021Article
- Serotonin in Animal Cognition and Behavior.International journal of molecular sciences · 2020Review
- Storage and erasure of behavioural experiences at the single neuron level.Scientific reports · 2019Article
- Monoamines, Insulin and the Roles They Play in Associative Learning in Pond Snails.Frontiers in behavioral neuroscience · 2019Review
- Responses of Withdrawal Interneurons to Serotonin Applications in Naïve and Learned Snails Are Different.Frontiers in cellular neuroscience · 2017Article
- Function of insulin in snail brain in associative learning.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
Corrections and comments
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The involvement of serotonin in mediating hunger-related changes in behavioral state has been described in many invertebrates. However, the mechanisms by which hunger signals to serotonergic cells remain unknown. We tested the hypothesis that serotonergic neurons can directly sense the concentration of glucose, a metabolic indicator of nutritional state. In the snail Lymnaea stagnalis, we demonstrate that completely isolated pedal serotonergic neurons that control locomotion changed their biophysical characteristics in response to glucose application by lowering membrane potential and decreasing the firing rate. Additionally, the excitatory response of the isolated serotonergic neurons to the neuroactive microenvironment of the pedal ganglia was significantly lowered by glucose application. Because hunger has been reported to increase the activity of select neurons and their responses to the pedal ganglia microenvironment, these responses to glucose are in accordance with the hypothesis that direct glucose signaling is involved in the mediation of the hunger-related behavioral state.
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