ArticleSudanese journal of paediatrics2014
Cystic fibrosis in Sudanese children: First report of 35 cases.
Article in Sudanese journal of paediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Fungal infections in Sudan: An underestimated health problem.PLoS neglected tropical diseases · 2023Article
- The burden of cystic fibrosis in North Africa.Frontiers in genetics · 2023Review
- Cystic fibrosis in South Africa: spectrum of disease and determinants of outcome.ERJ open research · 2021Article
- The future of cystic fibrosis care: a global perspective.The Lancet. Respiratory medicine · 2020Review
- Cystic fibrosis on the African continent.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Review
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Authors and funding
11 authors.
Funding
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Abstract
Cystic fibrosis is the most common severe genetic disorder among children of European descent. It is much less common in Africans and Asians. It affects most critically the lungs causing chronic lung disease, failure to thrive and social deprivation. This is a retrospective review of 35 Sudanese patients with confirmed cystic fibrosis. About 60% of cases presented before the age of 5 years and male to female ratio was 1.7:1.0. Consanguinity was reported in 25 of the families. The main presenting features were productive cough, wheeze and clubbing. The chest X-ray showed variable degrees of hyperinflation, collapse, cystic, fibrotic changes and bronchiectasis involving both upper and lower lobes with blurring of cardiac border and hilar vasculature in the majority of cases. The sweat chloride was between 70 and 140 mmol/l in 83% of the patients (positive > 60 mmol/l). Three patients underwent DNA study and confirmed to have cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations. Gene study was not available for the rest of the patients. To our knowledge this is the first report of confirmed cases of cystic fibrosis in Sudanese patients.
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27493388PMC4949914What OpenQuestion holds
Registered trials
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