Evidence map›Paper›PMID 27493234›Full record

ArticleCephalalgia : an international journal of headache2017

Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine.

Jun Zhao, Dara Bree, Michael G Harrington, Andrew M Strassman, Dan Levy

Open access · bronzeAbstract read
In one paragraph

Article in Cephalalgia : an international journal of headache, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  5. Meningeal Mechanisms and the Migraine Connection.Annual review of neuroscience · 2023
    Review
  6. Article
  7. Article
  8. Typical subdural contrast effusion secondary to endovascular treatment of a pediatric pial arteriovenous fistula.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jun Zhao1 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Dara Bree1 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Michael G Harrington3 Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, USA.
Andrew M Strassman1 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Dan Levy1 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harvard University · USBeth Israel Deaconess Medical Center · USHuntington Medical Research Institutes · US

Funding

MECHANISMS OF CSD-EVOKED PERSISTENT ACTIVATION OF MENINGEAL NOCICEPTORSR01NS078263 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEVY, DAN · 2013 to 2022
$3.1M
Peripheral Mechanisms of Posttraumatic HeadacheR01NS086830 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEVY, DAN · 2014 to 2018
$1.9M
Calvarial periosteal afferents in post-traumatic headacheR21NS077882 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEVY, DAN · 2011 to 2012
$479k
Rodent Behavioral Model of Ongoing Headache PainR21NS085510 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STRASSMAN, ANDREW MARK · 2013 to 2014
$476k
NINDS NIH HHS R01 NS078263NINDS NIH HHS R01 NS086830NINDS NIH HHS R21 NS077882NINDS NIH HHS R21 NS085510
6 · The paper itself

Abstract

Background Application of inflammatory mediators to the cranial dura has been used as a method to activate and sensitize neurons in the meningeal sensory pathway in preclinical behavioral studies of headache mechanisms. However, the relatively high concentrations and volumes used in these studies raise the question of whether the applied agents might pass through the dura to act directly on central neurons, thus bypassing the dural afferent pathway. Methods We used a radiolabeling approach to quantify the meningeal permeability of two of the inflammatory mediators, 5-HT and PGE

Indexed as

AnimalsBrainDinoprostoneDisease Models, AnimalDura MaterInflammationMaleMigraine DisordersNeuronsPermeabilityRats, Sprague-DawleySerotoninDinoprostoneSerotoninheadache modelsInflammatory mediatorsmeningeal permeabilityrat

Identifiers

PMID27493234
PMCPMC5774025
OpenAlexW2491620993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.