ArticleAngewandte Chemie (International ed. in English)2016
Accelerating Enzymatic Catalysis Using Vortex Fluidics.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Effect of vortex fluidic device and its combined treatment with ultrasonication on the conformational changes of soy protein isolate.Ultrasonics sonochemistry · 2025Article
- Room-Temperature Vortex Fluidic Flow Chemistry Synthesis of Full Color Carbon Dots.ChemSusChem · 2025Article
- Nanogold Foundry Involving High-Shear-Mediated Photocontact Electrification in Water.Small science · 2024Article
- Vortex fluidic regulated phospholipid equilibria involving liposomes down to sub-micelle size assemblies.Nanoscale advances · 2024Article
- Theoretical Improvements in Enzyme Efficiency Associated with Noisy Rate Constants and Increased Dissipation.Entropy (Basel, Switzerland) · 2024Article
- Hydrogel-Film-Fabricated Fluorescent Biosensors with Aggregation-Induced Emission for Albumin Detection through the Real-Time Modulation of a Vortex Fluidic Device.Molecules (Basel, Switzerland) · 2023Article
- Vortex Fluidic Mediated Oxidative Sulfitolysis of Oxytocin.Molecules (Basel, Switzerland) · 2022Article
- Sub-micron moulding topological mass transport regimes in angled vortex fluidic flow.Nanoscale advances · 2021Article
- Vortex Fluidic-Mediated Fabrication of Fast Gelated Silica Hydrogels with Embedded Laccase Nanoflowers for Real-Time Biosensing under Flow.ACS applied materials & interfaces · 2020Article
- Vortex fluidic mediated encapsulation of functional fish oil featuring in situ probed small angle neutron scattering.NPJ science of food · 2020Article
- Article
- Three-step-in-one synthesis of supercapacitor MWCNT superparamagnetic magnetite composite material under flow.Nanoscale advances · 2019Article
- Neutron imaging and modelling inclined vortex driven thin films.Scientific reports · 2019Article
- Vortex fluidic mediated food processing.PloS one · 2019Article
- Laser-Ablated Vortex Fluidic-Mediated Synthesis of Superparamagnetic Magnetite Nanoparticles in Water Under Flow.ACS omega · 2018Article
- Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis.ACS catalysis · 2018Article
- Vortex Fluidic Chemical Transformations.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Review
- Ten-Minute Protein Purification and Surface Tethering for Continuous-Flow Biocatalysis.Angewandte Chemie (International ed. in English) · 2017Article
- Rapid protein immobilization for thin film continuous flow biocatalysis.Chemical communications (Cambridge, England) · 2016Article
- Harnessing Thin-Film Continuous-Flow Assembly Lines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Enzymes catalyze chemical transformations with outstanding stereo- and regio-specificities, but many enzymes are limited by their long reaction times. A general method to accelerate enzymes using pressure waves contained within thin films is described. Each enzyme responds best to specific frequencies of pressure waves, and an acceleration landscape for each protein is reported. A vortex fluidic device introduces pressure waves that drive increased rate constants (kcat ) and enzymatic efficiency (kcat /Km ). Four enzymes displayed an average seven-fold acceleration, with deoxyribose-5-phosphate aldolase (DERA) achieving an average 15-fold enhancement using this approach. In solving a common problem in enzyme catalysis, a powerful, generalizable tool for enzyme acceleration has been uncovered. This research provides new insights into previously uncontrolled factors affecting enzyme function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.