ArticleNature communications2016
LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Lymphotoxin beta receptorInfection and immunity · 2025Article
- ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.Nature communications · 2025Article
- Endogenous thymic regeneration: restoring T cell production following injury.Nature reviews. Immunology · 2025Review
- Generation and repair of thymic epithelial cells.The Journal of experimental medicine · 2024Review
- LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB.Cell death and differentiation · 2024Article
- Age-related epithelial defects limit thymic function and regeneration.Nature immunology · 2024Article
- The Proteostasis of Thymic Stromal Cells in Health and Diseases.The protein journal · 2024Review
- Systematic analysis of the prognostic value and immunological function of LTBR in human cancer.Aging · 2024Article
- Intravital two-photon microscopy of the native mouse thymus.PloS one · 2024Article
- Mesenchymal stromal cells in the thymus.Inflammation and regeneration · 2022Review
- Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.eLife · 2022Article
- The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis.Frontiers in immunology · 2022Article
- Signaling Crosstalks Drive Generation and Regeneration of the Thymus.Frontiers in immunology · 2022Review
- T-Cell Progenitors As A New Immunotherapy to Bypass Hurdles of Allogeneic Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2022Review
- Thymus Functionality Needs More Than a Few TECs.Frontiers in immunology · 2022Review
- Lymphotoxin: from the physiology to the regeneration of the thymic function.Cell death and differentiation · 2021Review
- A 2020 View of Thymus Stromal Cells in T Cell Development.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Non-Epithelial Stromal Cells in Thymus Development and Function.Frontiers in immunology · 2021Review
- Thymic Egress Is Regulated by T Cell-Derived LTβR Signal andFrontiers in immunology · 2021Article
- RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous thymic homing of haematopoietic progenitor cells (HPCs) via the blood is critical for normal T-cell development. However, the nature and the differentiation programme of specialized thymic endothelial cells (ECs) controlling this process remain poorly understood. Here using conditional gene-deficient mice, we find that lymphotoxin beta receptor (LTβR) directly controls thymic ECs to guide HPC homing. Interestingly, T-cell deficiency or conditional ablation of T-cell-engaged LTβR signalling results in a defect in thymic HPC homing, suggesting the feedback regulation of thymic progenitor homing by thymic products. Furthermore, we identify and characterize a special thymic portal EC population with features that guide HPC homing. LTβR is essential for the differentiation and homeostasis of these thymic portal ECs. Finally, we show that LTβR is required for T-cell regeneration on irradiation-induced thymic injury. Together, these results uncover a cellular and molecular pathway that governs thymic EC differentiation for HPC homing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.