ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- 4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Altered cerebrovascular haemodynamics in Parkinson's disease: Insights from 4D flow MRI.NPJ Parkinson's disease · 2026Article
- Article
- Cerebral Venous Insufficiency as a Contributing Factor in Dementia: An Emerging Hypothesis.Stroke (Hoboken, N.J.) · 2026Review
- Imaging blood to periarterial CSF flow coupling using 4D flow MRI and an ultra-high-performance head-only gradient system.Fluids and barriers of the CNS · 2025Article
- Quantitative evaluation of low-frequency oscillations using real-time phase-contrast MRI during drowsiness.Fluids and barriers of the CNS · 2025Article
- Assessing cerebral microvascular pulsatility using flow pulsatile-resolved pseudo-continuous arterial spin labeling MRI.Magnetic resonance in medicine · 2025Article
- Arterial-optimized 4D-flow MRI for quantifying flow and pulsatility in venous sinuses and large cerebral veins.Scientific reports · 2025Article
- Assessing cerebral microvascular volumetric with high-resolution 4D cerebral blood volume MRI at 7 T.Nature cardiovascular research · 2025Article
- Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.Experimental physiology · 2025Review
- Simultaneous Assessment of Arterial Pulsatility Across Multiple Segments of Cerebral Arteries Using Multiband Dual-VENC Phase-Contrast MRI.NMR in biomedicine · 2025Article
- The microcirculation, the blood-brain barrier, and the neurovascular unit in health and Alzheimer disease: The aberrant pericyte is a central player.Pharmacological reviews · 2025Review
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- MVP-VSASL: measuring MicroVascular Pulsatility using velocity-selective arterial spin labeling.Magnetic resonance in medicine · 2025Article
- Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction.npj women's health · 2025Review
- Enlarged perivascular spaces in the basal ganglia region are associated with white matter interstitial fluid content via deep medullary vein dysfunction.Frontiers in human neuroscience · 2025Article
- Dynamic evolution of postoperative hemodynamics in moyamoya angiopathy: a quantitative assessment of 4D Flow MRI and prognostic relevance.Frontiers in neurology · 2025Article
- Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Assessing Cerebral Microvascular Volumetric Pulsatility with High-Resolution 4D CBV MRI at 7T.medRxiv : the preprint server for health sciences · 2024Article
- Measuring global cerebrovascular pulsatility transmission using 4D flow MRI.Scientific reports · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Cerebral blood flow, arterial pulsation, and vasomotion may be important indicators of cerebrovascular health in aging and diseases of aging such as Alzheimer's disease. Noninvasive markers that assess these characteristics may be helpful in the study of co-occurrence of these diseases and potential additive and interacting effects. In this study, 4D flow MRI was used to measure intra-cranial flow features with cardiac-gated phase contrast MRI in cranial arteries and veins. Mean blood flow and pulsatility index as well as the transit time of the peak flow from the middle cerebral artery to the superior sagittal sinus were measured in a total of 104 subjects comprising of four groups: (a) subjects with Alzheimer's disease, (b) age-matched controls, (c) subjects with mild cognitive impairment, and (d) a group of late middle-aged with parental history of sporadic Alzheimer's disease. The Alzheimer's disease group exhibited: a significant decrease in mean blood flow in the superior sagittal sinus, transverse sinus, middle cerebral artery, and internal carotid arteries; a significant decrease of the peak and end diastolic blood flow in the middle cerebral artery and superior sagittal sinus; a faster transmission of peak flow from the middle cerebral artery to the superior sagittal sinus and increased pulsatility index along the carotid siphon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.