ReviewTrends in cardiovascular medicine2017
Atrial fibrillation driver mechanisms: Insight from the isolated human heart.
Review in Trends in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Structural determinants of re-entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre-resolution imaging of human heart.The Journal of physiology · 2026Article
- The mechanism of electrical remodeling in atrial fibrillation and current research status of natural drugs and active ingredients inhibiting atrial electrical remodeling.Frontiers in cardiovascular medicine · 2026Review
- Isolated Perfused Hearts for Cardiovascular Research: An Old Dog with New Tricks.Journal of cardiovascular translational research · 2024Review
- In Vitro Models for Improved Therapeutic Interventions in Atrial Fibrillation.Journal of personalized medicine · 2023Review
- Genetic and non-genetic risk factors associated with atrial fibrillation.Life sciences · 2022Review
- Spatial concentration and distribution of phase singularities in human atrial fibrillation: Insights for the AF mechanism.Journal of arrhythmia · 2021Article
- Time-Averaged Wavefront Analysis Demonstrates Preferential Pathways of Atrial Fibrillation, Predicting Pulmonary Vein Isolation Acute Response.Frontiers in physiology · 2021Article
- Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease.Heart rhythm O2 · 2020Article
- Granger Causality-Based Analysis for Classification of Fibrillation Mechanisms and Localization of Rotational Drivers.Circulation. Arrhythmia and electrophysiology · 2020Article
- Linking Electrical Drivers With Atrial Cardiomyopathy for the Targeted Treatment of Atrial Fibrillation.Frontiers in physiology · 2020Review
- Unified mechanism of local drivers in a percolation model of atrial fibrillation.Physical review. E · 2019Article
- Paroxysmal supraventricular tachycardia and risk of ischemic stroke: A systematic review and meta-analysis.Journal of arrhythmia · 2019Article
- The hemodynamic and atrial electrophysiologic consequences of chronic left atrial volume overload in a controllable canine model.The Journal of thoracic and cardiovascular surgery · 2018Article
- Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation.Frontiers in physiology · 2018Article
- Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex Vivo.Journal of the American Heart Association · 2017Article
- Fibrosis and Atrial Fibrillation: Computerized and Optical Mapping; A View into the Human Atria at Submillimeter Resolution.JACC. Clinical electrophysiology · 2017Review
- [Remodeling of the aging heart : Sinus node dysfunction and atrial fibrillation].Herzschrittmachertherapie & Elektrophysiologie · 2017Article
- Maintenance of Atrial Fibrillation: Are Reentrant Drivers With Spatial Stability the Key?Circulation. Arrhythmia and electrophysiology · 2016Review
- Understanding the transition from paroxysmal to persistent atrial fibrillation.Physical review researchArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although there have been great technological advances in the treatment of atrial fibrillation (AF), current therapies remain limited due to a narrow understanding of AF mechanisms in the human heart. This review will highlight our recent studies on explanted human hearts where we developed and employed a novel functional-structural mapping approach by integrating high-resolution simultaneous endo-epicardial and panoramic optical mapping with 3D gadolinium-enhanced MRI to define the spatiotemporal characteristics of AF drivers and their structural substrates. The results allow us to postulate that the primary mechanism of AF maintenance in human hearts is a limited number of localized intramural microanatomic reentrant AF drivers anchored to heart-specific 3D fibrotically insulated myobundle tracks, which may remain hidden to clinical single-surface electrode mapping. We suggest that ex vivo human heart studies, by using an integrated 3D functional and structural mapping approach, will help to reveal defining features of AF drivers as well as validate and improve clinical approaches to detect and target these AF drivers in patients with cardiac diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.