ArticleScientific reports2016
The Secreted Protease PrtA Controls Cell Growth, Biofilm Formation and Pathogenicity in Xylella fastidiosa.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- PrtA-mediated flagellar turnover is essential for robust biofilm development inApplied and environmental microbiology · 2025Article
- Characterization and Genomics of Pectinolytic Bacteria Isolated from Soft Rot Symptomatic Produce.Pathogens (Basel, Switzerland) · 2024Article
- Transcriptome and Secretome Analyses of EndophyteMicroorganisms · 2023Article
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- Comparative Genomics ofMicroorganisms · 2022Article
- Expression of putative effectors of different Xylella fastidiosa strains triggers cell death-like responses in various Nicotiana model plants.Molecular plant pathology · 2022Article
- An Apoplastic Effector Pat-1Frontiers in plant science · 2022Article
- A Secreted Chorismate Mutase fromInternational journal of molecular sciences · 2021Article
- Xylella fastidiosa: A reemerging plant pathogen that threatens crops globally.PLoS pathogens · 2021Review
- Complete Genome Sequence ofFrontiers in microbiology · 2021Article
- Proteome Analysis of Walnut Bacterial Blight Disease.International journal of molecular sciences · 2020Article
- Bacterial Vector-Borne Plant Diseases: Unanswered Questions and Future Directions.Molecular plant · 2020Review
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- Genome sequence and spore germination-associated transcriptome analysis of Corynespora cassiicola from cucumber.BMC microbiology · 2020Article
- Genome-Scale Investigation of the Metabolic Determinants Generating Bacterial Fastidious Growth.mSystems · 2020Article
- Infections of thePlants (Basel, Switzerland) · 2019Article
- Patterns of inter- and intrasubspecific homologous recombination inform eco-evolutionary dynamics of Xylella fastidiosa.The ISME journal · 2019Article
- Trans-Graft Protection Against Pierce's Disease Mediated by Transgenic Grapevine Rootstocks.Frontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pierce's disease (PD) is a deadly disease of grapevines caused by the Gram-negative bacterium Xylella fastidiosa. Though disease symptoms were formerly attributed to bacteria blocking the plant xylem, this hypothesis is at best overly simplistic. Recently, we used a proteomic approach to characterize the secretome of X. fastidiosa, both in vitro and in planta, and identified LesA as one of the pathogenicity factors of X. fastidiosa in grapevines that leads to leaf scorching and chlorosis. Herein, we characterize another such factor encoded by PD0956, designated as an antivirulence secreted protease "PrtA" that displays a central role in controlling in vitro cell proliferation, length, motility, biofilm formation, and in planta virulence. The mutant in X. fastidiosa exhibited reduced cell length, hypermotility (and subsequent lack of biofilm formation) and hypervirulence in grapevines. These findings are supported by transcriptomic and proteomic analyses with corresponding plant infection data. Of particular interest, is the hypervirulent response in grapevines observed when X. fastidiosa is disrupted for production of PrtA, and that PD-model tobacco plants transformed to express PrtA exhibited decreased symptoms after infection by X. fastidiosa.
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