ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2017
Predictors of health-related quality of life and association with survival may identify colorectal cancer patients at high risk of poor prognosis.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Calidad de Vida: a systematic review of quality of life in Latino cancer survivors in the USA.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Pooled it
- Patient-reported outcomes as predictors of survival in patients with bowel cancer: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Pooled it
- Racial and Ethnic Disparity in Preference-Weighted Quality of Life: Findings from the Selenium and Vitamin E Cancer Prevention Trial.Population health management · 2025Trial
- Preoperative social frailty and short-term postoperative outcomes in gastrointestinal cancer surgery: a multicentre prospective cohort study in China.World journal of surgical oncology · 2026Observational
- Symptom impact and health-related quality of life (HRQoL) assessment by cancer stage: a narrative literature review.BMC cancer · 2024Review
- Patient-Reported Quality of Life at Diagnosis in Adolescent and Young Adults With Cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2024Article
- Health-Related Quality of Life Scores and Values as Predictors of Mortality: A Scoping Review.Journal of general internal medicine · 2023Article
- Gender Differences in Psychosocial Outcomes and Coping Strategies of Patients with Colorectal Cancer: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Persisting Deficits in Health-Related Quality of Life of Colorectal Cancer Survivors 14-24 Years Post-Diagnosis: A Population-Based Study.Current oncology (Toronto, Ont.) · 2023Article
- Determinants of quality of life of cancer patients at a tertiary care medical city in Riyadh, Saudi Arabia.Frontiers in psychiatry · 2023Article
- Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Observational
- Association Between Health-Related Quality of Life and Progression-Free Survival in Patients With Advanced Cancer: A Secondary Analysis of SWOG Clinical Trials.JCO oncology practice · 2022Article
- Predictors of Quality of Life Six Years after Curative Colorectal Cancer Surgery: Results of the Prospective Multicenter Study.Medicina (Kaunas, Lithuania) · 2022Article
- Patterns of racial/ethnic disparities in baseline health-related quality of life and relationship with overall survival in patients with colorectal cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Health-related quality of life in Malaysian gastrointestinal cancer patients and their family caregivers-a comparison study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- When do defecation function and quality of life recover for patients with non-ostomy and ostomy surgery of rectal cancer?BMC surgery · 2020Article
- Health-Related Predictors of Quality of Life in Cancer Patients in Saudi Arabia.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Article
- Testing of a health-related quality of life model in patients with heart failure: A cross-sectional, correlational study.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeTo investigate the mediators of health-related quality of life (HR-QoL) in colorectal cancer (CRC) patients and effect on overall survival.
methodsWe analyzed baseline (within 1 year of diagnosis) SF-12v1 questionnaire data from 3734 CRC patients and assessed the differences in mental composite scores (MCS) and physical composite scores (PCS) by socio-demographics and risks of poor HR-QoL by these factors. Hazard ratios were generated using univariate Cox regression for MCS and PCS dichotomized using the normalized scoring-based mean of 50 and survival estimates generated using the Kaplan-Meier method.
resultsDifferences in MCS and PCS were identified by sex, age, education level, alcohol use, tobacco use, and stage. Race, marital status, and cancer site differed only by PCS. Being female, never married, former alcohol user, or with stage IV disease significantly increased risk of a poor HR-QoL, with magnitudes of risk from 1.25- to 1.97-fold. Higher education level had a protective effect (MCS: P
conclusionsOur findings identify potential mediators for HR-QoL and suggest that baseline HR-QoL assessment may be prognostic for CRC.
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