Trial reportApplied health economics and health policy2017
The Cost-Effectiveness of Oral Nutrition Supplementation for Malnourished Older Hospital Patients.
Trial report in Applied health economics and health policy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Oral nutritional interventions in frail older people who are malnourished or at risk of malnutrition: a systematic review.Health technology assessment (Winchester, England) · 2022Pooled it
- Pooled it
- Supportive interventions for enhancing dietary intake in malnourished or nutritionally at-risk adults.The Cochrane database of systematic reviews · 2016Pooled it
- Trial
- Economic Evaluation of Individualized Nutritional Support for Hospitalized Patients with Chronic Heart Failure.Nutrients · 2022Trial
- Economic evaluation of an extended nutritional intervention in older Australian hospitalized patients: a randomized controlled trial.BMC geriatrics · 2018Trial
- Identification of Circulating Lipidomic Biomarkers of Malnutrition Risk among Oncology Patients in the Total Cancer Care (TCC) Study: A Cross-Sectional Analysis.The Journal of nutrition · 2026Article
- Comparing characteristics and outcomes between hospitalized adults on a pea protein or dairy/soy protein formulas: initial findings.Journal of comparative effectiveness research · 2026Article
- Early combined parenteral and enteral nutrition support for patients over 80 years old with non-operative intestinal obstruction.Frontiers in nutrition · 2026Article
- Healthcare Resource Utilization During a Multimodal Nutritional Program with Oral Nutritional Supplements in Malnourished Outpatients.Nutrients · 2025Article
- Cost-Effectiveness of Oral Nutritional Supplements in Malnourished or at Risk of Disease-Related Malnutrition Cancer Patients in North Macedonia.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Article
- Nutrition-Focused Quality Improvement Programs in Pediatric Care.Children (Basel, Switzerland) · 2024Article
- Article
- Education Intervention Has the Potential to Improve Short-Term Dietary Pattern among Older Adults with Undernutrition.Geriatrics (Basel, Switzerland) · 2023Article
- Cost-Effectiveness Analysis of Standardized Clinical Nutrition Diagnosis and Treatment Pathway in Patients with Pulmonary Infection.Computational and mathematical methods in medicine · 2022Article
- Cost-effectiveness analysis of oral nutritional supplements with nutritional counselling in head and neck cancer patients undergoing radiotherapy.Cost effectiveness and resource allocation : C/E · 2021Article
- Guidelines for parenteral and enteral nutrition in geriatric patients in China.Aging medicine (Milton (N.S.W)) · 2020Article
- Budget Impact Analysis of a Home-Based Nutrition Program for Adults at Risk for Malnutrition.American health & drug benefits · 2020Article
- Efficacy and Efficiency of Nutritional Support Teams.Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition, which is associated with increased medical complications in older hospitalized patients, can be attenuated by providing nutritional supplements.
objectiveThis study evaluates the cost effectiveness of a specialized oral nutritional supplement (ONS) in malnourished older hospitalized patients.
methodsWe conducted an economic evaluation alongside a multicenter, randomized, controlled clinical trial (NOURISH Study). The target population was malnourished older hospitalized patients in the USA. We used 90-day (base case) and lifetime (sensitivity analysis) time horizons. The study compared a nutrient-dense ONS, containing high protein and β-hydroxy-β-methylbutyrate to placebo. Outcomes included health-care costs, measured as the product of resource use and per unit cost; quality-adjusted life-years (QALYs) (90-day time horizon); life-years (LYs) saved (lifetime time horizon); and the incremental cost-effectiveness ratio (ICER). All costs were inflated to 2015 US dollars.
resultsIn the base-case analysis, 90-day treatment group costs averaged US$22,506 per person, compared to US$22,133 for the control group. Treatment group patients gained 0.011 more QALYs than control group subjects, reflecting the treatment group's significantly greater probability of survival through 90 days' follow-up, as reported by the clinical trial. Hence, the 90-day follow-up period ICER was US$33,818/QALY. Assuming a lifetime time horizon, estimated treatment group life expectancy exceeded control group life expectancy by 0.71 years. Hence, the lifetime ICER was US$524/LY. The follow-up period for the trial was relatively short. Some of the patients were lost to follow-up, thus reducing collection of health-care utilization data during the clinical trial.
conclusionOur findings suggest that the investigative ONS cost-effectively extends the lives of malnourished hospitalized patients.
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