Evidence map›Paper›PMID 27492417›Full record

ArticleFunctional & integrative genomics2016

Genomic and functional features of the biosurfactant producing Bacillus sp. AM13.

Shraddha Shaligram, Shreyas V Kumbhare, Dhiraj P Dhotre, Manohar G Muddeshwar, Atya Kapley, Neetha Joseph, Hemant P Purohit, Yogesh S Shouche, Shrikant P Pawar

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In one paragraph

Article in Functional & integrative genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Identification and characterization ofFrontiers in microbiology · 2023
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  4. Molecular characterization of a novel strain ofFrontiers in plant science · 2022
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  5. Article
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  9. Frontiers in bioengineering and biotechnology · 2020
    Review
  10. Genomic Insights of HalophilicFrontiers in microbiology · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shraddha ShaligramDepartment of Biochemistry, Government Medical College, Nagpur, 440009, Maharashtra, India.
Shreyas V KumbhareMicrobial Culture Collection, National Centre for Cell Science, Pune, 411007, Maharashtra, India.
Dhiraj P DhotreMicrobial Culture Collection, National Centre for Cell Science, Pune, 411007, Maharashtra, India.
Manohar G MuddeshwarDepartment of Biochemistry, Government Medical College, Nagpur, 440009, Maharashtra, India. mmuddeshwar2016@gmail.com.
Atya KapleyEnvironmental Genomics Division, National Environmental Engineering Research Institute, CSIR Nehru Marg, Nagpur, 440020, India.
Neetha JosephMicrobial Culture Collection, National Centre for Cell Science, Pune, 411007, Maharashtra, India.
Hemant P PurohitEnvironmental Genomics Division, National Environmental Engineering Research Institute, CSIR Nehru Marg, Nagpur, 440020, India.
Yogesh S ShoucheMicrobial Culture Collection, National Centre for Cell Science, Pune, 411007, Maharashtra, India.
Shrikant P PawarMicrobial Culture Collection, National Centre for Cell Science, Pune, 411007, Maharashtra, India. shrikantpawar@nccs.res.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic studies provide deeper insights into secondary metabolites produced by diverse bacterial communities, residing in various environmental niches. This study aims to understand the potential of a biosurfactant producing Bacillus sp. AM13, isolated from soil. An integrated approach of genomic and chemical analysis was employed to characterize the antibacterial lipopeptide produced by the strain AM13. Genome analysis revealed that strain AM13 harbors a nonribosomal peptide synthetase (NRPS) cluster; highly similar with known biosynthetic gene clusters from surfactin family: lichenysin (85 %) and surfactin (78 %). These findings were substantiated with supplementary experiments of oil displacement assay and surface tension measurements, confirming the biosurfactant production. Further investigation using LCMS approach exhibited similarity of the biomolecule with biosurfactants of the surfactin family. Our consolidated effort of functional genomics provided chemical as well as genetic leads for understanding the biochemical characteristics of the bioactive compound.

Indexed as

BacillusBacterial ProteinsGenome, BacterialGenomicsPeptide SynthasesSecondary MetabolismSurface-Active AgentsBacterial ProteinsPeptide SynthasesSurface-Active AgentsBacillus genomeBacterial natural productsBiosurfactantLipopeptidesNRPS

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.