Evidence map›Paper›PMID 27492388›Full record

ArticlePediatric radiology2016

Feasibility, tolerability and safety of pediatric hyperpolarized

Laura L Walkup, Robert P Thomen, Teckla G Akinyi, Erin Watters, Kai Ruppert, John P Clancy, Jason C Woods, Zackary I Cleveland

Abstract read
In one paragraph

Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  9. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Article
  11. Article
  12. HyperpolarizedAcademic radiology · 2024
    Article
  13. Initial feasibility and challenges of hyperpolarizedMagnetic resonance in medicine · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Image Phenotyping of Preterm-Born Children Using HyperpolarizedAmerican journal of respiratory and critical care medicine · 2023
    Article
  18. Article
  19. PediatricJournal of magnetic resonance imaging : JMRI · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura L WalkupCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 5033, Cincinnati, OH, 45229, USA.
Robert P ThomenCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 5033, Cincinnati, OH, 45229, USA.
Teckla G AkinyiCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 5033, Cincinnati, OH, 45229, USA.
Erin WattersCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 5033, Cincinnati, OH, 45229, USA.
Kai RuppertCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 5033, Cincinnati, OH, 45229, USA.
John P ClancyDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jason C WoodsCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 5033, Cincinnati, OH, 45229, USA.
Zackary I ClevelandCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 5033, Cincinnati, OH, 45229, USA. zackary.cleveland@cchmc.org.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
MR predictors of infection, inflammation, and structural lung damage in CFR01HL116226 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLANCY, JOHN PAUL · 2012 to 2015
$2.1M
NCATS NIH HHS UL1 TR001425NHLBI NIH HHS R01 HL116226NHLBI NIH HHS R01 HL131012NHLBI NIH HHS T32 HL007752
6 · The paper itself

Abstract

backgroundHyperpolarized

objectiveTo assess the feasibility, safety and tolerability of hyperpolarized MATERIALS AND

methodsSeventeen healthy control subjects (ages 6-15 years, 11 boys) and 11 children with cystic fibrosis (ages 8-16 years, 4 boys) underwent

resultsAll children tolerated multiple doses of

conclusionThe feasibility, safety and tolerability of

Indexed as

AdolescentChildContrast MediaCystic FibrosisFeasibility StudiesFemaleHumansImage EnhancementLungMagnetic Resonance ImagingMaleXenon IsotopesContrast MediaXenon IsotopesChildrenCystic fibrosisHyperpolarized xenonLungsMagnetic resonance imaging

Identifiers

PMID27492388
PMCPMC5083137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.