ArticleBMC complementary and alternative medicine2016
Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae).
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 41 citations in OpenAlex.
- Evaluation of the Antidiarrheal Activity of 80% Methanolic Extract and Solvent Fractions of Calpurnia aurea (Ait.) Benth. (Fabaceae) Roots in Swiss Albino Mice.BioMed research international · 2026Article
- Evaluation of In Vivo Antidiarrheal Activities of 80% Methanol Extract and Solvent Fractions of Peels ofEvidence-based complementary and alternative medicine : eCAM · 2024Article
- Antidiarrheal activities of methanolic crude extract and solvent fractions of the root ofHeliyon · 2023Article
- Evaluation of Anti-Diarrheal Activities of the 80% Methanol Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Neuropharmacological and Antidiarrheal Potentials ofCurrent issues in molecular biology · 2022Article
- Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice.BMC complementary medicine and therapies · 2022Article
- Article
- Aqueous Tuber Extracts ofFrontiers in pharmacology · 2021Article
- Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Antidiarrheal Effect of 80% Methanol Extract and Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Ethnomedicinal Knowledge of Traditional Healers in Roi Et, Thailand.Plants (Basel, Switzerland) · 2020Article
- Chemotherapeutic Potential ofAntibiotics (Basel, Switzerland) · 2020Article
- Evaluation of the Antidiarrheal Activity of Hydromethanol Crude Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Medicinal Plants Used for Treatment of Diarrhoeal Related Diseases in Ethiopia.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Antiplasmodial activity of Indigofera spicata root extract against Plasmodium berghei infection in mice.Malaria journal · 2017Article
- Antidiarrheal activity of methanolic extract of the root bark ofJournal of experimental pharmacology · 2016Article
- Evaluation of the Antispasmodic and Antisecretory Activities of the 80% Methanol Extracts ofJournal of evidence-based integrative medicineArticle
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTill now many of medicinal plants having claimed therapeutic value traditionally are waiting scientific verification of their efficacy and safety. Accordingly this study is conducted to evaluate the antidiarrheal activity of hydromethanolic root extract of Indigofera spicata Forssk. in castor oil induced diarrhea model, misoprostol induced secretion model and its antimotility activity using charcoal as a marker.
methodsIn all the three models the animals were randomly allocated into five groups of six animals each and then group I mice were received 1 ml/100 g normal saline, group II were treated with standard drug as a positive control whereas group III, IV and V were treated with 100, 200 and 400 mg/kg extract doses, respectively. Statistical significance of differences in the mean of number of defecations, fluid content of faces, intestinal fluid accumulation ratio, intestinal fluid weight and distance travelled by charcoal between groups was analyzed by SPSS version-21 using one way ANOVA followed by Tukey's post hoc multiple comparison.
resultThe hydromethanolic crude extract of Indigofera spicata at 200 and 400 mg/kg mg/kg doses showed statistically significant (p < 0.05) inhibition of the frequency of defecation and weight difference of the fluid content of the faces compared to the negative controls. For those doses the percentage inhibition of diarrheal feces was 43.62 and 53.51 %, respectively. The antisecretary activity of the extract in terms of fluid accumulation ratio was not found significant but in terms of intestinal fluid weight, all the extract doses revealed significant (p < 0.05) inhibition. Unlike the standard drug, the antimotility activity of the extract was not found statistically significant compared to the negative control.
conclusionRoot of Indigofera spicata Forssk. has shown promising antidiarrheal activity which validates its traditional use. Further studies are needed and possibly the plant may serve as a potential source of new agent in the therapeutic armamentarium of diarrhea.
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