Evidence map›Paper›PMID 27491874›Full record

ArticleEuropean radiology2017

Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate.

Pieter J L De Visschere, Anne Vral, Gianpaolo Perletti, Eva Pattyn, Marleen Praet, Vittorio Magri, Geert M Villeirs

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Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pieter J L De VisschereDepartment of Radiology, Ghent University Hospital, 0DPP, De Pintelaan 185, 9000, Ghent, Belgium. pieter.devisschere@uzgent.be.
Anne VralDepartment of Basic Medical Sciences, Ghent University Hospital, Ghent, Belgium.
Gianpaolo PerlettiDepartment of Basic Medical Sciences, Ghent University Hospital, Ghent, Belgium.
Eva PattynDepartment of Radiology, Ghent University Hospital, 0DPP, De Pintelaan 185, 9000, Ghent, Belgium.
Marleen PraetDepartment of Pathology, Ghent University Hospital, Ghent, Belgium.
Vittorio MagriUrology Clinic, Instituti Clinici di Perfezionamento, Milano, Italy.
Geert M VilleirsDepartment of Radiology, Ghent University Hospital, 0DPP, De Pintelaan 185, 9000, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify the multiparametric magnetic resonance imaging (mpMRI) characteristics of normal, benign and malignant conditions in the prostate.

methodsFifty-six histopathological whole-mount radical prostatectomy specimens from ten randomly selected patients with prostate cancer (PC) were matched with corresponding transverse mpMRI slices. The mpMRI was performed prior to biopsy and consisted of T2-weighted imaging (T2-WI), diffusion-weighted imaging (DWI), dynamic contrast-enhanced imaging (DCE) and magnetic resonance spectroscopic imaging (MRSI).

resultsIn each prostate specimen, a wide range of histopathological conditions were observed. They showed consistent but overlapping characteristics on mpMRI. Normal glands in the transition zone showed lower signal intensity (SI) on T2-WI, lower ADC values and lower citrate peaks on MRSI as compared to the peripheral zone (PZ) due to sparser glandular elements and more prominent collagenous fibres. In the PZ, normal glands were iso-intense on T2-WI, while high SI areas represented cystic atrophy. Mimickers of well-differentiated PC on mpMRI were inflammation, adenosis, HG-PIN and post-atrophic hyperplasia.

conclusionEach prostate is a unique mix of normal, benign and/or malignant areas that vary in extent and distribution resulting in very heterogeneous characteristics on mpMRI. Understanding the main concepts of this mpMRI-histopathological correlation may increase the diagnostic confidence in reporting mpMRI. KEYPOINTS: • In each prostate specimen a wide range of histopathological conditions was observed. • Interpretation of mpMRI may be difficult because benign conditions may mimic PC. • High signal intensity areas in the PZ on T2-WI represented cystic atrophy. • The TZ showed sparser glands and more collagenous fibres than the PZ.

Indexed as

AgedBiopsyDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingHumansImage EnhancementKallikreinsMagnetic Resonance ImagingMaleMiddle AgedProstateProstatectomyProstate-Specific AntigenProstatic HyperplasiaProstatic NeoplasmsKallikreinsKLK3 protein, humanProstate-Specific AntigenInflammationMagnetic resonance imagingProstate cancerProstatic atrophyProstatic hyperplasia

Identifiers

PMID27491874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.