ArticleBritish journal of sports medicine2018
Ten-year change in sedentary behaviour, moderate-to-vigorous physical activity, cardiorespiratory fitness and cardiometabolic risk: independent associations and mediation analysis.
Article in British journal of sports medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Association between sedentary behavior and dementia: a systematic review and meta-analysis of cohort studies.BMC psychiatry · 2025Pooled it
- Pooled it
- The Effect of Sedentary Behaviour on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Effectiveness of eHealth Interventions on Moderate-to-Vigorous Intensity Physical Activity Among Patients in Cardiac Rehabilitation: Systematic Review and Meta-analysis.Journal of medical Internet research · 2023Pooled it
- Association Between Patient Factors and the Effectiveness of Wearable Trackers at Increasing the Number of Steps per Day Among Adults With Cardiometabolic Conditions: Meta-analysis of Individual Patient Data From Randomized Controlled Trials.Journal of medical Internet research · 2022Pooled it
- The trajectory of patterns of light and sedentary physical activity among females, ages 14-23.PloS one · 2019Trial
- A 12-week Exercise Intervention Among Older Adults With Chronic Coronary Syndrome: Changes and Associations of Movement Behaviors and Cardiovascular Risk Factors.European journal of sport science · 2026Observational
- Objective Analysis of Movement Behaviours and Cardiometabolic Health in Sub-Saharan Africans Living in the UK: A Cross Sectional Study.Health science reports · 2026Article
- Mobile Interventions for Reducing Sedentary Behavior and Promoting Physical Activity Among Office Workers: Bibliometric Study.Health education & behavior : the official publication of the Society for Public Health Education · 2026Review
- The Association Between Sedentary Behavior and Cardiovascular Disease Risk: An Analysis Based on NHANES Data.Cardiovascular therapeutics · 2026Article
- Effects of reducing sedentary behaviour on cardiovascular health, skeletal muscle oxidative capacity and functional exercise capacity in sedentary adults: a randomised controlled trial.BMJ open sport & exercise medicine · 2026Article
- Modelling the direct and indirect associations between anthropometric and behavioural factors when predicting atherogenic risk index (TC/HDL-C) ratio.International journal of obesity (2005) · 2025Article
- Ocean for Health: A Transdisciplinary Framework to Accelerate Research on Ocean-Human Health Connections.Environmental science & technology · 2025Review
- Inactivity-mediated molecular adaptations: Insights from a preclinical model of physical activity reduction.Physiological reports · 2024Article
- Fitness-related physical activity intensity explains most of the association between accelerometer data and cardiometabolic health in persons 50-64 years old.British journal of sports medicine · 2024Article
- Independent and joint effects of self-reported physical activity and sedentary behaviors on mortality in community-dwelling older persons: a prospective cohort study.BMC geriatrics · 2024Article
- Isotemporal substitution of accelerometer-derived sedentary behavior and physical activity on physical fitness in young children.Scientific reports · 2024Article
- Association between physical activity and sedentary behavior and gestational diabetes mellitus: a Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
- The potential harms of sedentary behaviour on cardiometabolic health are mitigated in highly active adults: a compositional data analysis.Journal of activity, sedentary and sleep behaviors · 2023Article
- Older adults' perspectives on physical activity and sedentary behaviour within their home using socio-ecological model.PloS one · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundWe aimed to study the independent associations of 10-year change in sedentary behaviour (SB), moderate-to-vigorous physical activity (MVPA) and objectively measured cardiorespiratory fitness (CRF), with concurrent change in clustered cardiometabolic risk and its individual components (waist circumference, fasting glucose, high-density lipoprotein (HDL) cholesterol, triglycerides and blood pressure). We also determined whether associations were mediated by change in CRF (for SB and MVPA), waist circumference (for SB, MVPA and CRF) and dietary intake (for SB).
methodsA population-based sample of 425 adults (age (mean±SD) 55.83±9.40; 65% men) was followed prospectively for 9.62±0.52 years. Participants self-reported SB and MVPA and performed a maximal cycle ergometer test to estimate peak oxygen uptake at baseline (2002-2004) and follow-up (2012-2014). Multiple linear regression and the product of coefficients method were used to examine independent associations and mediation effects, respectively.
resultsGreater increase in SB was associated with more detrimental change in clustered cardiometabolic risk, waist circumference, HDL cholesterol and triglycerides, independently of change in MVPA. Greater decrease in MVPA was associated with greater decrease in HDL cholesterol and increase in clustered cardiometabolic risk, waist circumference and fasting glucose, independent of change in SB. Greater decrease in CRF was associated with more detrimental change in clustered cardiometabolic risk and all individual components. Change in CRF mediated the associations of change in SB and MVPA with change in clustered cardiometabolic risk, waist circumference and, only for MVPA, HDL cholesterol. Change in waist circumference mediated the associations between change in CRF and change in clustered cardiometabolic risk, fasting glucose, HDL cholesterol and triglycerides.
conclusionsA combination of decreasing SB and increasing MVPA, resulting in positive change in CRF, is likely to be most beneficial towards cardiometabolic health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.