ArticleJournal of natural medicines2017
Structure and hemolytic activity relationships of triterpenoid saponins and sapogenins.
Article in Journal of natural medicines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Structure-activity Relationships of Triterpenoid Saponins Across Phylogenetically Diverse Organisms.Journal of chemical ecology · 2026Article
- A comprehensive review on plant-derived bioactive saponins as promising antimicrobial agents: from bioavailability challenges, molecular mechanistic insights to therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Harnessing Thalassochemicals: Marine Saponins as Bioactive Agents in Nutraceuticals and Food Technologies.Marine drugs · 2025Review
- Evaluation of the antiproliferative, cytotoxic and phytochemical properties of Zimbabwean medicinal plants used in cancer treatment.BMC complementary medicine and therapies · 2025Article
- A potential therapeutic effect of sea cucumberJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- "Radix Saniculae": Phytochemical Characterization and Potential Adulteration of an Austrian Traditional Wound-Healing Agent.Plants (Basel, Switzerland) · 2025Article
- Asteroid Saponins: A Review of Their Bioactivity and Selective Cytotoxicity.Marine drugs · 2024Review
- Preparation and characterization of micellar nanoparticles using crude saponins from five Congolese plant species.Pharmaceutical science advances · 2024Article
- Structural Characterization and Profiles of Saponins from Two Algerian Sea Cucumbers.Molecules (Basel, Switzerland) · 2024Article
- Plant-based nanoparticles targeting malaria management.Frontiers in pharmacology · 2024Review
- Recent advances in the anti-tumor activities of saponins through cholesterol regulation.Frontiers in pharmacology · 2024Review
- An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives.Frontiers in pharmacology · 2024Review
- Pharmacological overview of hederagenin and its derivatives.RSC medicinal chemistry · 2023Review
- Saponin Fraction CIL1 fromPharmaceutics · 2023Article
- Horse Chestnut Saponins-Escins, Isoescins, Transescins, and Desacylescins.Molecules (Basel, Switzerland) · 2023Article
- Wide-genome selection of lactic acid bacteria harboring genes that promote the elimination of antinutritional factors.Frontiers in plant science · 2023Article
- Evaluation of nutritional value, bioactivity and mineral content of quinoa bran in China and its potential use in the food industry.Current research in food science · 2023Article
- The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin fromFrontiers in pharmacology · 2023Review
- Functional block copolymer micelles based on poly (jasmine lactone) for improving the loading efficiency of weakly basic drugs.RSC advances · 2022Article
- Identification and Characterization of Bifunctional Drimenol Synthases of Marine Bacterial Origin.ACS chemical biology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the hemolytic activity of 41 commercially available triterpenoid saponins and sapogenins derived from three types of structural skeletons. Structure-activity relationships were established by comparing the structural characteristics of both the aglycone and sugar moieties among the tested compounds. The majority of oleanane-type sapogenins had stronger hemolytic effects than those of the ursane and dammarane types. The presence of polar regions on sapogenins, such as a carboxyl (COOH) at position 28, an α-hydroxyl (α-OH) at position 16, and/or a β-hydroxyl (β-OH) at position 2, significantly enhanced hemolysis. Meanwhile, the introduction of an α-OH at position 2 or a methyl hydroxyl (CH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.