ArticleAmerican journal of ophthalmology2016
Localized Changes in Retinal Nerve Fiber Layer Thickness as a Predictor of Localized Functional Change in Glaucoma.
Article in American journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Structure-function correlates in anterior visual pathway lesions: a systematic review.Eye (London, England) · 2025Pooled it
- Retinal layer assessments as potential biomarkers for brain atrophy in the Rhineland Study.Scientific reports · 2022Trial
- Relations Between Pulsatility in the Optic Nerve Head or Peripapillary Retinal Vessels and the Rate of Progression in Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Vascular Density and Retinal Structure Relationships Across Sectors and Regions of the Optic Nerve in Patients With Primary Open Angle Glaucoma.Journal of glaucoma · 2025Article
- Comparison of Efficacy and Ocular Surface Assessment Between Preserved and Preservative-Free Brimonidine/Timolol Fixed-Combination Eye Drops in Glaucoma Patients: A Parallel-Grouped, Randomized Trial.Journal of clinical medicine · 2025Article
- Vascular resistance indices are higher in the superior than inferior optic nerve head and retina.Experimental eye research · 2024Article
- Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects.Investigative ophthalmology & visual science · 2023Article
- Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.American journal of ophthalmology · 2021Article
- Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Time Lag Between Functional Change and Loss of Retinal Nerve Fiber Layer in Glaucoma.Investigative ophthalmology & visual science · 2020Article
- Association of Birth Weight with Peripapillary Retinal Nerve Fiber Layer Thickness in Adulthood-Results from a Population-Based Study.Investigative ophthalmology & visual science · 2020Article
- Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2019Article
- Determinants of Macular Layers and Optic Disc Characteristics on SD-OCT: The Rhineland Study.Translational vision science & technology · 2019Article
- Optical Coherence Tomography Segmentation Errors of the Retinal Nerve Fiber Layer Persist Over Time.Journal of glaucoma · 2019Article
- Three dimensional neuro-retinal rim thickness and retinal nerve fiber layer thickness using high-definition optical coherence tomography for open-angle glaucoma.Japanese journal of ophthalmology · 2018Article
- Repeatability and reproducibility of retinal nerve fibre layer thickness measurements with the iVue-100 optical coherence tomographer.African health sciences · 2018Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine how well rates of localized retinal nerve fiber layer thickness (RNFLT) change correlate with rates of sensitivity change at corresponding locations in the visual field in glaucoma.
designRetrospective cohort study.
methodsThree hundred and sixty-four eyes of 191 participants with suspected or confirmed glaucoma, as judged by experienced clinicians, were tested every 6 months with perimetry and optical coherence tomography (OCT). For each 24-2 visual field location, the corresponding sectoral peripapillary RNFLT was defined using a 30-degree sector, centered on the angle of nerve fiber entry into the optic nerve head. Rates of change of pointwise sensitivity and sectoral RNFLT were calculated over the last 8 visits at which reliable data were obtained. Passing-Bablok regression was used to predict the rate of pointwise sensitivity change from the rate of sectoral RNFLT change, for each location.
resultsRates of sectoral RNFLT change were significantly predictive of rates of pointwise sensitivity change at all locations in the field. Correlations were modest, averaging 0.15, ranging from 0.03 to 0.25 depending on the location. A 1 μm/y more rapid thinning in corresponding sectors was associated with 0.3 dB/y more rapid loss in the superior visual field but less than 0.1 dB/y more rapid loss at many locations in the inferior visual field.
conclusionsLocalized RNFL thinning is associated with sensitivity loss at corresponding locations in the visual field, and their rates of change are significantly correlated. Peripapillary RNFLT may be used to monitor localized changes caused by glaucoma that have measurable consequences for a patient's vision.
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