SynthesisBMC psychiatry2016
The assessment of depression in people with multiple sclerosis: a systematic review of psychometric validation studies.
Synthesis in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Best practice exercise for emerging depression in multiple sclerosis: A systematic review and meta-analysis.Clinical rehabilitation · 2024Pooled it
- Cognitive Assessment of Individuals with Multiple Sclerosis in the Arab World: a Systematic Review.Neuropsychology review · 2019Pooled it
- Psychometric properties of the PHQ-9 depression scale in people with multiple sclerosis: A systematic review.PloS one · 2019Pooled it
- The assessment of depression in people with multiple sclerosis: a systematic review of psychometric validation studies.BMC psychiatry · 2016Pooled it
- Pooled it
- Safety and Effectiveness of CinnomerArchives of Iranian medicine · 2023Trial
- Mediating effect of cognitive reserve on associations between processing speed and memory in older adults with and without multiple sclerosis.Neuropsychology · 2026Article
- Assessing the relation between fatigue and depression in multiples sclerosis: the impact of measurement choice.Frontiers in immunology · 2026Article
- Suicidal Ideation in Patients With Multiple Sclerosis and Its Association With Clinical and Demographic Characteristics.Brain and behavior · 2025Article
- Evidence of symptom specificity for depression in multiple sclerosis: A two sample Mendelian randomization study.Multiple sclerosis and related disorders · 2024Article
- Multiple Sclerosis and Depression: Translation and Adaptation of the Spanish Version of the Chicago Multiscale Depression Inventory and the Study of Factors Associated with Depressive Symptoms.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
- Impact of autologous HSCT on the quality of life and fatigue in patients with relapsing multiple sclerosis.Scientific reports · 2022Article
- Major depression favors the expansion of Th17-like cells and decrease the proportion of CD39Cellular and molecular life sciences : CMLS · 2022Article
- Communication, Coordination, and Security for People with Multiple Sclerosis (COCOS-MS): a randomised phase II clinical trial protocol.BMJ open · 2022Article
- Impact of Moderate Individually Tailored Physical Activity in Multiple Sclerosis Patients with Fatigue on Functional, Cognitive, Emotional State, and Postural Stability.Brain sciences · 2021Article
- Article
- Immunomodulation Eliminates Inflammation in the Hippocampus in Experimental Autoimmune Encephalomyelitis, but Does Not Ameliorate Anxiety-Like Behavior.Frontiers in immunology · 2021Article
- The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis.F1000Research · 2020Article
- The Psychological Impact of COVID-19 Pandemic on People With Multiple Sclerosis.Frontiers in neurology · 2020Article
- Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study.JMIR research protocols · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of depression in people with multiple sclerosis (PwMS) is high; however, symptoms common to both conditions makes measurement difficult. There is no high quality overview of validation studies to guide the choice of depression inventory for this population.
methodsA systematic review of studies validating the use of generic depression inventories in people with MS was conducted using MEDLINE and PsycINFO. Studies validating the use of depression inventories in PwMS and published in English were included; validation studies of tests for cognitive function and general mental health were excluded. Eligible studies were then quality assessed using the COSMIN checklist and findings synthesised narratively by instrument and validity domain.
resultsTwenty-one studies (N = 5,991 PwMS) evaluating 12 instruments were included in the review. Risk of bias varied greatly between instrument and validity domain.
conclusionsThe review of validation studies was constrained by poor quality reporting and outcome reporting bias. Well-conducted evaluations of some instruments are unavailable for some validity domains. This systematic review provides an evidence base for trade-offs in the selection of an instrument for assessing self-reported symptoms of depression in research or clinical practice involving people with MS. We make detailed and specific recommendations for where further research is needed.
trial registrationPROSPERO CRD42014010597.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.