Evidence map›Paper›PMID 27491424›Full record

ArticleJournal of autism and developmental disorders2016

Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders.

Laya Ekhlaspour, Charumathi Baskaran, Karen Joanie Campoverde, Natalia Cano Sokoloff, Ann M Neumeyer, Madhusmita Misra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Bone health in children and youth with ASD: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Practical Guide for Improving Orthopaedic Care in Children with Autism Spectrum Disorder.Journal of the Pediatric Orthopaedic Society of North America · 2023
    Review
  8. Article
  9. Article
  10. Altered Bone Status in Rett Syndrome.Life (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Nutrition and Bone Density in Boys with Autism Spectrum Disorder.Journal of the Academy of Nutrition and Dietetics · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laya EkhlaspourPediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, 55 Fruit Street, Yawkey 6c, Boston, MA, 02114, USA. lekhlaspour@mgh.harvard.edu.ORCID 0000-0002-3263-1419
Charumathi BaskaranPediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, 55 Fruit Street, Yawkey 6c, Boston, MA, 02114, USA.
Karen Joanie CampoverdeNeuroendocrine Unit, Massachusetts General Hospital, 101 Merrimac St, 6th Floor, Office 615, Boston, MA, 02114, USA.
Natalia Cano SokoloffNeuroendocrine Unit, Massachusetts General Hospital, 101 Merrimac St, 6th Floor, Office 615, Boston, MA, 02114, USA.
Ann M NeumeyerLurie Center for Autism, Massachusetts General Hospital and Harvard Medical School, One Maguire Road, Lexington, MA, 02421, USA.
Madhusmita MisraPediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, 55 Fruit Street, Yawkey 6c, Boston, MA, 02114, USA.

Funding

Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
NICHD NIH HHS K24 HD071843
6 · The paper itself

Abstract

Patients with autism spectrum disorder (ASD) are at increased risk for fracture, and peri-pubertal boys with ASD have lower bone mineral density (BMD) than controls. Data are lacking regarding BMD in older adolescents with ASD. We compared BMD using dual-energy X-ray absorptiometry in 9 adolescents/young adults with ASD against 9 typically developing matched controls. Patients with ASD and controls were excluded if they had other underlying conditions that may affect bone. Compared to controls, patients with ASD had (i) lower femoral neck and hip BMD Z-scores, and (ii) lower spine, femoral neck and hip height adjusted BMD Z-scores even after controlling for BMI. Understanding the underlying pathophysiology will be key to developing therapies to improve BMD and reduce fracture risk.

Indexed as

Absorptiometry, PhotonAdolescentAdultAutism Spectrum DisorderBody Mass IndexBone DensityFemaleFractures, SpontaneousHumansMaleReference ValuesYoung AdultAdolescentAutism spectrum disorderBody mass indexBone mineral densityDual energy X-ray absorptiometry

Identifiers

PMID27491424
PMCPMC5074906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.