Evidence map›Paper›PMID 27491357›Full record

ArticleChemical communications (Cambridge, England)2016

Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system.

Saemi O Poelma, Seung Soo Oh, Sameh Helmy, Abigail S Knight, G Leslie Burnett, H Tom Soh, Craig J Hawker, Javier Read de Alaniz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Reversible Photoswitching of Donor-Acceptor Stenhouse Adducts in Water.Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. The influence of molecular design on structure-property relationships of a supramolecular polymer prodrug.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Review
  13. Review
  14. Green Light-Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  15. Review
  16. Article
  17. Stimuli-Responsive Drug Release from Smart Polymers.Journal of functional biomaterials · 2019
    Review
  18. Article
  19. Lipid-DNAs as Solubilizers of mTHPC.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saemi O PoelmaDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu.
Seung Soo OhMaterials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
Sameh HelmyDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu.
Abigail S KnightMaterials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
G Leslie BurnettMaterials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
H Tom SohMaterials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA and Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, USA.
Craig J HawkerDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu and Materials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
Javier Read de AlanizDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu.

Funding

Midwest Progenitor Cell ConsortiumU01HL099773 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI THOMSON, JAMES ALEXANDER · 2009 to 2015
$7.8M
NHLBI NIH HHS U01 HL099773
6 · The paper itself

Abstract

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material - donor-acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light.

Identifiers

PMID27491357
PMCPMC5015652

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.